ROLE OF INTERLEUKIN-1 IN THE ACTIVATION OF LYMPHOCYTES-T
ROLE OF INTERLEUKIN-1 IN THE ACTIVATION OF LYMPHOCYTES-T
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DOI：
10.1073/pnas.85.24.9699
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发表时间：
1988-12-01
影响因子：
11.1
通讯作者：
ABBAS, AK
中科院分区：
文献类型：
--
作者：
LICHTMAN, AH;CHIN, J;ABBAS, AK
T淋巴细胞的活化需要它们通过克隆型抗原受体以及非抗原特异性共刺激因子的刺激，其中最好的定义是细胞因子白细胞介素1（IL-1）。最近的研究表明，小鼠CD 4+辅助性T淋巴细胞由两个不重叠的亚群组成，它们选择性地利用白细胞介素2（IL-2）或白细胞介素4作为其自分泌生长因子，分别称为Th 1和Th 2细胞。我们现在表明，IL-1可作为Th 2细胞增殖的共刺激因子，但对Th 1细胞克隆的增殖无作用，并且只有Th 2细胞表达IL-1的高亲和力受体。Th 1和Th 2细胞分泌的自分泌促生长淋巴因子在通过抗原-受体-CD 3复合物刺激后发生，既不依赖于IL-1，也不受IL-1的影响。这些发现表明，T淋巴细胞的活化可以分为两个阶段，淋巴因子分泌和增殖，只有增殖需要共刺激因子，如IL-1。此外，IL-1通过诱导IL-2的分泌或IL-2受体的表达而作为共刺激物起作用的流行观点可能并不普遍适用，因为产生IL-2的Th 1克隆不表达IL-1的受体并且对该细胞因子不敏感。
The activation of T lymphocytes requires their stimulation via clonotypic antigen receptors as well as nonantigen-specific costimulators, the best defined of which is the cytokine interleukin 1 (IL-1). Recent studies have shown that murine CD4+ helper T lymphocytes consist of two nonoverlapping subsets that selectively utilize interleukin 2 (IL-2) or interleukin 4 as their autocrine growth factors and are called Th1 and Th2 cells, respectively. We now show that IL-1 functions as a costimulator for the proliferation of Th2 but not of Th1 clones and only Th2 cells express high-affinity receptors for IL-1. Secretion of autocrine growth-promoting lymphokines by th1 and Th2 cells occurs after stimulation via the antigen-receptor-CD3 complex and is neither dependent on nor affected by IL-1. These findings suggest that the activation of T lymphocytes can be divided into two stages, lymphokine secretion and proliferation, and only proliferation requires costimulators such as IL-1. Moreover, the prevailing view that IL-1 functions as a costimulator by inducing secretion of IL-2 or expression of IL-2 receptors may not be generally applicable, because IL-2-producing Th1 clones do not express receptors for IL-1 and are insensitive to this cytokine.