Superior temporal and premotor brain areas necessary for biological motion perception
Superior temporal and premotor brain areas necessary for biological motion perception
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DOI：
10.1093/brain/awm162
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发表时间：
2007-09-01
期刊：
影响因子：
14.5
通讯作者：
Saygin, Ayse Pinar
中科院分区：
文献类型：
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作者：
Saygin, Ayse Pinar
我们在一大批单侧脑卒中患者（N = 60）中测试了生物运动知觉。与年龄匹配的对照组相比，左右半球病变患者均明显受损。基于体素的病变分析显示，颞上区和运动前额区病变对生物运动感知的影响最大。此外，每个区域的影响是独立的，不能归因于其他区域病变的间接影响。当我们在一个单独的实验中探索从神经健康对照中收集的功能磁共振成像（fMRI）数据与病变图的关系时，我们发现这两种方法的发现是一致的。因此，我们确立了颞上区和运动前区不仅参与生物运动知觉，而且与生物运动知觉缺陷有因果关系。虽然每个区域的确切功能角色仍有待确定，但在许多研究中，该网络与动作刺激的感知有关，因此患者的缺陷可能反映了无法有效地参与动作观察系统。
We tested biological motion perception in a large group of unilateral stroke patients (N = 60). Both right and left hemisphere lesioned patients were significantly impaired compared with age-matched controls. Voxel-based lesion analyses revealed that lesions in superior temporal and premotor frontal areas had the greatest effect on biological motion perception. Moreover, the effect in each region was independent, and not attributable to indirect effects of lesions in the other area. When we explored functional magnetic resonance imaging ( fMRI) data collected from neurologically healthy controls in a separate experiment in relation to the lesion maps, we found that the two methods converged on their findings. We thus establish that superior temporal and premotor areas are not only involved in biological motion perception, but also have causal relationships to deficits in biological motion perception. While the precise functional roles of each region remain to be identified, this network has been implicated in the perception of action stimuli in many studies and as such patients' deficits may reflect an inability to effectively engage the action observation system.