The Impact of Acutely Elevated Intraocular Pressure on the Porcine Optic Nerve Head
The Impact of Acutely Elevated Intraocular Pressure on the Porcine Optic Nerve Head
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DOI：
10.1167/iovs.10-7137
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发表时间：
2011-08-01
影响因子：
4.4
通讯作者：
Yu, Dao-Yi
中科院分区：
文献类型：
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作者：
Fatehee, Naeem;Yu, Paula K.;Yu, Dao-Yi
目的.研究急性眼内压（IOP）升高对猪视神经乳头（ONH）杯状区、板前区和筛板区的影响。使用光谱域光学相干断层扫描（OCT）对10头猪ONH进行离体成像。用压头操纵IOP，并用压力传感器测量IOP。在0 mm Hg下进行参考扫描，然后以7 mm Hg步长进行进一步扫描，直至49 mm Hg。在不同的IOP下测量中心OCT B扫描的形态测量参数，并分析IOP与这些参数变化之间的关系。随着IOP从0增加到49 mm Hg，平均横截杯面积增加（28% ± 3%，P < 0.001），筛板面积减少（18% ± 2%，P < 0.001），板前组织面积减少（5.5% ± 0.5%，P < 0.001）。多因素回归分析显示，筛杯面积的变化主要与筛板位置和厚度的变化有关（r = 0.89，P < 0.001）。在猪ONH中，IOP的急性升高导致ONH的后移位以及筛板和前板组织变形。（Invest Ophthalmol维斯科学。2011; 52：6192-6198）DOI：10.1167/iovs.107137
PURPOSE. To investigate the effects of acute elevations in intraocular pressure (IOP) on the cup, prelaminar, and lamina cribrosa regions of the porcine optic nerve head (ONH).METHODS. Ex vivo imaging of 10 porcine ONHs was performed using spectral-domain optical coherence tomography (OCT). The IOP was manipulated with a pressure head and measured with a pressure transducer. Reference scans were taken at 0 mm Hg, before further scanning was performed at 7-mm Hg steps, up to 49 mm Hg. Morphometric parameters were measured across centrally located OCT B-scans at different IOPs, and the relationship between IOP and changes in these parameters was analyzed.RESULTS. As IOP increased from 0 to 49 mm Hg, mean cross-sectional cup area increased (28% +/- 3%, P < 0.001), lamina cribrosa area decreased (18% +/- 2%, P < 0.001), and prelaminar tissue area decreased (5.5% +/- 0.5%, P < 0.001). Multivariate regression demonstrated that most of the change in cup area is associated with changes in both lamina cribrosa position and thickness (r = 0.89, P < 0.001).CONCLUSIONS. Acute elevations in IOP were shown to result in posterior displacement of ONH, as well as lamina cribrosa and prelaminar tissue deformation in the porcine ONH. (Invest Ophthalmol Vis Sci. 2011; 52: 6192-6198) DOI:10.1167/iovs.107137