Assessment of amniotic and polyurethane membrane dressings in the treatment of burns
Assessment of amniotic and polyurethane membrane dressings in the treatment of burns
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DOI：
10.1016/j.burns.2009.09.003
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发表时间：
2010-08-01
期刊：
影响因子：
2.7
通讯作者：
Mohamed, B. A.
中科院分区：
文献类型：
--
作者：
Adly, O. A.;Moghazy, A. M.;Mohamed, B. A.
由于同种异体移植物和异种移植物在伊斯兰国家不可用，羊膜似乎是深度烧伤管理的有效替代品。它被证明的生物活性和适中的价格表明，它可能上级合成dressing.46例患者参加了这项随机，对照临床试验在烧伤科在苏伊士运河大学医院，伊斯梅利亚，埃及。所有年龄组和两种性别均纳入研究。仅纳入烧伤总体表面积小于50%的患者，从而最大限度地减少两组的脱落。所有人都是二度或三度。这些患者被随机分配到第I组：羊膜（Biomembrane）敷料，或第II组：聚氨酯膜（Tegadamine）敷料。与第II组相比，第I组的感染率明显较低，更换敷料的频率也较低。他们还持续较少的电解质和白蛋白损失。羊膜组的愈合速度明显快于聚氨酯组。此外，当使用Biomembrane时，疼痛明显减轻。基于这些发现，我们建议在伊斯兰国家和犹太人群中使用冻干的伽马辐照羊膜作为同种异体移植物和异种移植物的有效替代品。(C)2009 Elsevier Ltd和ISBI。All rights reserved.
As allograft and xenografts are not available in Islamic countries, amniotic membrane seems to be an effective alternative in the management of deep burns. Its proven bioactivities and modest price suggest that it might be superior to synthetic dressings.Forty-six patients were enrolled in this randomized, controlled clinical trial conducted in the Burn Unit at Suez Canal University Hospital, Ismailia, Egypt. All age groups and both gender were included in the study. Only patients with less than 50% total body surface area burned were included, thus minimizing the dropouts in both groups. All were either second or third degree. These patients were randomly assigned either to group I: amniotic membrane (Biomembrane) dressing, or group II: polyurethane membrane (Tegaderm) dressing.Those in group I demonstrated a significantly lower rate of infection and required less frequent dressing changes than those in group II. They also sustained less electrolyte and albumin loss. The rate of healing in the amniotic membrane group was significantly faster than in the polyurethane group. Furthermore, pain was significantly less when Biomembrane was used.Based on these findings, we recommend the use of lyophilized gamma-irradiated amniotic membrane as an effective alternative for allograft and xenografts in Islamic countries and the Jewish population. (C) 2009 Elsevier Ltd and ISBI. All rights reserved.