Detection of the mcr-1 Colistin Resistance Gene in Carbapenem-Resistant Enterobacteriaceae from Different Hospitals in China
Detection of the mcr-1 Colistin Resistance Gene in Carbapenem-Resistant Enterobacteriaceae from Different Hospitals in China
复制标题
国内不同医院碳青霉烯类耐药肠杆菌中mcr-1粘菌素耐药基因的检测。
DOI：
10.1128/aac.00440-16
复制
发表时间：
2016-08-01
影响因子：
4.9
通讯作者：
Chen, Liang
中科院分区：
文献类型：
--
作者：
Yu, Hua;Qu, Fen;Chen, Liang
质粒介导的粘菌素耐药基因mcr-1在碳青霉烯类耐药肠杆菌科（CRE）临床分离株中的传播对全球健康构成重大威胁。在此，我们报告了从中国两个省的3名患者中采集的3株携带mcr-1的碳青霉烯类耐药大肠埃希菌菌株的鉴定。我们的结果表明，携带mcr-1的CRE菌株已开始在中国的不同医院传播。此外，本报告首次描述了mcr-1整合入碳青霉烯类耐药大肠杆菌的染色体。coli菌株。
The spread of the plasmid-mediated colistin resistance gene, mcr-1, into carbapenem-resistant Enterobacteriaceae (CRE) clinical isolates poses a significant threat to global health. Here we report the identification of three mcr-1-harboring carbapenem-resistant Escherichia coli strains, collected from three patients in two provinces in China. Our results show that mcr-1-harboring CRE strains have started to spread in different hospitals in China. In addition, this report presents the first description of chromosomal integration of mcr-1 into a carbapenem-resistant E. coli strain.