Fear-potentiated startle in rats.
Fear-potentiated startle in rats.
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DOI：
10.1002/0471142301.ns0811as14
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发表时间：
2001-05-01
影响因子：
--
通讯作者：
Davis, M
中科院分区：
文献类型：
--
作者：
Davis, M
恐惧增强惊吓测量在先前与足电击配对的提示存在的情况下由突然噪声引起的惊吓反射的增加。它包括一个初始的训练阶段，其中一个线索，如一盏灯，与脚电击配对，然后是一个稍后的测试阶段，在有或没有线索的情况下引起惊吓。因此，它涉及联想学习，在保持测试中测量的联想记忆，以及在线索存在的情况下的条件性恐惧。干扰学习、记忆或恐惧和焦虑的药物可以改变恐惧增强的惊吓，这取决于它们何时与训练和测试有关。
Fear-potentiated startle measures the increase in the startle reflex elicited by a sudden noise in the presence of a cue that has previously been paired with footshock. It involves an initial training session in which a cue, such as a light, is paired with footshock, and then a later test session in which startle is elicited in the presence or absence of the cue. It thus involves associative learning, memory for that association measured during the retention test, and conditioned fear in the presence of the cue. Drugs that interfere with learning, memory, or fear and anxiety can alter fear-potentiated startle depending on when they are given with respect to training and testing.