REVACCINATION RESPONSE OF CATTLE AS A FUNCTION OF THE 140S FOOT AND MOUTH-DISEASE ANTIGEN DOSE
REVACCINATION RESPONSE OF CATTLE AS A FUNCTION OF THE 140S FOOT AND MOUTH-DISEASE ANTIGEN DOSE
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DOI：
10.1016/0021-9975(84)90028-8
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发表时间：
1984-01-01
影响因子：
0.8
通讯作者：
BOGE, A
中科院分区：
文献类型：
--
作者：
BLACK, L;RWEYEMAMU, M;BOGE, A
将50头成年牛再分成两组，分别接种含5 .mu的口蹄疫疫苗。G或0.01 .mu。g O1BFS 1860 140S抗原/ 3ml剂量。4个月后，他们又被分成5人一组，注射含有140S抗原浓度从54 .mu不等的疫苗。G-7 ng/ 3ml剂量。定期出血，血清中和抗体滴度显示一次接种和二次接种140S抗原剂量均影响再接种应答。无记忆血清抗体对数反应与二次疫苗中抗原剂量呈线性对数关系。
Adult cattle (50) were subdivided in 2 equal groups and inoculated with foot-and-mouth disease vaccines containing either 5 .mu.g or 0.01 .mu.g of O1BFS 1860 140S antigen/3 ml dose. Four mo. later they were subdivided into groups of 5 and injected with vaccines containing concentrations of the 140S antigen ranging from 54 .mu.g-7 ng/3 ml dose. Bleedings were carried out periodically and the serum neutralizing antibody titers showed that the revaccination responses were influenced by the dose of 140S antigen in both the primary and secondary vaccinations. A linear log relationship was demonstrated between the anamnestic serum antibody log response and the dose of antigen in the secondary vaccines.