Effects of pressure-induced stretch and convection on low-density lipoprotein and albumin uptake in the rabbit aortic wall
Effects of pressure-induced stretch and convection on low-density lipoprotein and albumin uptake in the rabbit aortic wall
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DOI：
10.1161/01.res.79.3.532
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发表时间：
1996-09-01
影响因子：
20.1
通讯作者：
Tedgui, A
中科院分区：
文献类型：
--
作者：
Meyer, G;Merval, R;Tedgui, A
在体外研究了压力驱动的对流和血管壁拉伸在低密度脂蛋白（LDL）和白蛋白跨动脉壁转运的压力相关变化的影响，在新鲜切除的兔胸主动脉保持在体内长度和加压在70，120，或160毫米汞柱30分钟。将不同直径（4、5或6 mm）的外部刚性聚酯套管穿过动脉节段的一半周围，以防止加压期间血管扩张。管腔内溶液含有I-131-LDL和I-125-白蛋白。使用连续冰冻切片技术，在包裹和未包裹的节段中测定LDL（C-LDL）和白蛋白（C-alb）跨壁的相对浓度的跨壁分布。在未包裹的节段中，C-alb在70和120 mm Hg之间均匀增加（P
The effects of pressure-driven convection and vessel wall stretching in the pressure-related changes in low-density lipoprotein (LDL) and albumin transport across the arterial wall were studied in vitro in freshly excised rabbit thoracic aorta held at in vivo length and pressurized at 70, 120, or 160 mm Hg for 30 minutes. External rigid polyester sleeves of various diameters (4, 5, or 6 mm) were passed around half of the arterial segments in order to prevent vessel distension during pressurization. The intraluminal solution contained I-131-LDL and I-125-albumin. The transmural distribution of relative concentrations of LDL (C-LDL) and albumin (C-alb) across the wall was determined in wrapped and unwrapped segments using a serial frozen-sectioning technique. In the unwrapped segments, C-alb increased uniformly between 70 and 120 mm Hg (P