Reduced cardiac 123I-MIBG scintigraphy in idiopathic REM sleep behavior disorder
Reduced cardiac 123I-MIBG scintigraphy in idiopathic REM sleep behavior disorder
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DOI：
10.1212/01.wnl.0000249313.25627.2e
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发表时间：
2006-12-26
期刊：
影响因子：
9.9
通讯作者：
Hirata, K.
中科院分区：
文献类型：
--
作者：
Miyamoto, T.;Miyamoto, M.;Hirata, K.
特发性REM睡眠行为障碍（RBD）可能代表前驱突触核蛋白病。我们报告显着减少心脏I-123-间碘苄胍摄取，符合交感神经末梢的损失，在特发性RBD。我们还证明，这种减少是相同的幅度与帕金森病患者中发现。这些结果与老年患者的特发性RBD是路易体病的一种形式的假设一致。
Idiopathic REM sleep behavior disorder (RBD) may represent prodromal synucleinopathies. We report markedly reduced cardiac I-123-metaiodobenzylguanidine uptake, consistent with the loss of sympathetic terminals, in idiopathic RBD. We also demonstrate that this reduction is of the same magnitude as that found in patients with Parkinson disease. The results are consistent with the hypothesis that idiopathic RBD in older patients is a forme fruste of Lewy body disease.