Praziquantel efficacy and long-term appraisal of schistosomiasis control in Pemba Island
Praziquantel efficacy and long-term appraisal of schistosomiasis control in Pemba Island
复制标题
DOI：
10.1111/j.1365-3156.2010.02488.x
复制
发表时间：
2010-05-01
影响因子：
3.3
通讯作者：
Haji, H. Juma
中科院分区：
文献类型：
--
作者：
Guidi, A.;Andolina, C.;Haji, H. Juma
目的确定吡喹酮（PZQ）在奔巴岛断断续续地大量使用20年后是否仍保持对血血吸虫的防治效果，并对血吸虫病控制规划的效果进行回顾性分析。方法采用尿滤过、血尿量、血尿量及卵活力测定方法，对一名奔巴学龄儿童进行PZQ治疗前后的检测。结果在服用PZQ后的第7周，尽管5%的患儿仍能通过尿液排出一些虫卵，但这些虫卵都不存活，这表明PZQ具有有效的杀血吸虫活性，随后死虫卵从宿主组织中缓慢释放。结论本研究人群未发现PZQ耐药迹象。对奔巴岛血吸虫病控制活动的总体回顾性分析显示，大规模给药对降低感染流行明显有效，但在药物分发中断后不久，流行率迅速恢复到干预前的水平。
P>ObjectiveTo determine whether praziquantel (PZQ) has retained its efficacy against Schistosoma haematobium on Pemba Island after 20 years of mass administration -albeit discontinuous- and to analyse retrospectively the performance of schistosomiasis control programmes.MethodsA sample of Pemba schoolchildren was examined before and after PZQ treatment by urine filtration, macro- and micro-haematuria and viability of excreted eggs.ResultsAlthough 5% of treated children continued to pass some eggs in the urine up to the seventh week after PZQ administration, none of these eggs was viable, indicating an effective schistosomicidal activity followed by a slow release of dead eggs from host tissues.ConclusionNo signs of PZQ resistance could be detected in the population under study. An overall retrospective analysis of schistosomiasis control activities in Pemba Island revealed that mass drug administration is clearly effective in reducing infection prevalence, but soon after interruption of drug distribution prevalence returns rapidly to pre-intervention levels.