Association of the TNF-α+489 G/A polymorphism with chronic obstructive pulmonary disease risk in Asians: meta-analysis
Association of the TNF-α+489 G/A polymorphism with chronic obstructive pulmonary disease risk in Asians: meta-analysis
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DOI：
10.4238/2015.may.18.12
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发表时间：
2015-01-01
影响因子：
0.4
通讯作者：
Ma, H. L.
中科院分区：
文献类型：
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作者：
Cui, K.;Ge, X. Y.;Ma, H. L.
肿瘤坏死因子-α+489G/A多态与慢性阻塞性肺疾病(COPD)的相关性仍然存在争议，因为研究小组规模小，不同研究的设计也不尽相同。在本研究中，运用Meta分析评估了+489G/A多态与COPD风险之间的关系。对报告肿瘤坏死因子-α+489G/A多态与慢性阻塞性肺疾病风险之间的关联的文章进行了全面搜索。在显性(AA+GA对GG)和等位基因(A对G)模型下计算合并优势比(OR)，95%可信区间(CI)。对异质性和发表偏倚进行了评估。本研究共纳入9篇文章，10篇符合条件的研究。在等位基因模型下，亚洲人群中+489G/A多态与慢性阻塞性肺疾病显著相关(OR=1.582，95%CI=1.035~2.419)。然而，在高加索人群中没有发现明显的差异。在两种模型下都发现了研究间异质性的有力证据，并且没有检测到发表偏倚。我们的结果表明，在亚洲人中，肿瘤坏死因子-α+489G/A多态的A等位基因可能在增加COPD风险中起作用，而在高加索人中则不是。还需要更多的研究来验证这一结论。
The association between the TNF-alpha + 489 G/A polymorphism and chronic obstructive pulmonary disease (COPD) remains controversial because of small group size and varied design among different studies. In the present study, a meta-analysis was conducted to assess the association between the + 489 G/A polymorphism and COPD risk. A comprehensive search was conducted to identify articles that have reported an association between the TNF-alpha + 489 G/A polymorphism and COPD risk. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated under both dominant (AA+GA vs GG genotypes) and allele (A vs G) models. Heterogeneity was assessed, as well as publication bias. Nine articles with ten eligible studies were included in this analysis. Significant association between the + 489 G/A polymorphism and COPD was identified in Asians under the allele model (OR = 1.582, 95% CI = 1.035-2.419). However, no significant difference was found in the Caucasian groups. Strong evidence for between-study heterogeneity was identified under both models, and no publication bias was detected. Our results indicated a potential role of the A allele of the TNF-alpha + 489 G/A polymorphism in increasing COPD risk in Asians, but not in Caucasians. Additional studies will be necessary to verify this conclusion.