Curcumin exerts anti-tumor effects on diffuse large B cell lymphoma via regulating PPARγ expression
Curcumin exerts anti-tumor effects on diffuse large B cell lymphoma via regulating PPARγ expression
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姜黄素通过调节 PPARγ 表达对弥漫性大 B 细胞淋巴瘤发挥抗肿瘤作用
DOI：
10.1016/j.bbrc.2019.12.129
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发表时间：
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期刊：
影响因子：
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通讯作者：
Zhang xi
中科院分区：
文献类型：
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作者：
Zhang Wei;Li Qiong;Yang Chao;Yang Huan;Rao Jun;Zhang xi
鉴于弥漫性大B细胞淋巴瘤(DLBCL)的高度异质性和对适当治疗的多样化需求，许多患者会复发或对现有治疗方案表现出耐药性，因此迫切需要探索新的治疗方案。姜黄素在多种肿瘤中都具有抗肿瘤的作用，本实验研究了姜黄素在体内外对人DLBCL的可能作用及其机制，发现姜黄素以浓度和时间依赖的方式抑制细胞活力，促进细胞凋亡，并使细胞周期停滞于G2期，这些作用是通过PPARγ促进和Akt/mTor途径失活而实现的。此外，姜黄素对人DLBCL细胞的作用可被PPARγ拮抗剂GW9662部分拮抗，并被PPARγ激动剂罗格列酮增强。综上所述，我们的结果表明姜黄素通过上调PPARγ的表达来抑制DLBCL细胞的增殖，我们的结果可能为DLBCL的治疗提供新的治疗途径和潜在的靶点。
Given the highly heterogeneity of diffuse large B cell lymphoma (DLBCL) and the diverse demands for proper treatment, many patients would relapse or show resistance to current therapeutic regimens, new treatment options are urgent to be explored. Curcumin harbored anti-tumor potential in various cancers, here, we investigated the possible effects and mechanism of curcumin on human DLBCL in vitro and in vivo, we found that curcumin inhibited cell viability in a concentration and time dependent manner, promoted cell apoptosis and arrested cell cycle at G2 phase, and these effects were mediated by PPARγ promotion and Akt/mTOR pathway inactivation. Furthermore, effects of curcumin on human DLBCL cells could be partly rescued by PPARγ antagonist GW9662, and enhanced by PPARγ agonist rosiglitazone. Taken together, our results demonstrated that curcumin inhibited the proliferation of DLBCL cells by up-regulating the expression of PPARγ, and our results might provide novel therapeutic approaches and a potential target to DLBCL treatment.