NUCLEOTIDE-SEQUENCE OF V-REL - THE ONCOGENE OF RETICULOENDOTHELIOSIS VIRUS
NUCLEOTIDE-SEQUENCE OF V-REL - THE ONCOGENE OF RETICULOENDOTHELIOSIS VIRUS
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DOI：
10.1073/pnas.80.20.6229
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发表时间：
1983-01-01
期刊：
影响因子：
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通讯作者：
GILDEN, RV
中科院分区：
文献类型：
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作者：
STEPHENS, RM;RICE, NR;GILDEN, RV
网状内皮组织增生症病毒(REV)携带的癌基因v-rel的核苷酸序列已经测定。有缺陷的转化基因组REV是通过将v-rel(1415个核苷酸)插入辅助病毒REV-A的env基因而产生的。预测的Rel蛋白(503个氨基酸)使用REV-A env启动子，并终止于env的p20E区域。由于没有检测到REV转化蛋白的天然抗血清，因此该核苷酸序列为其分离和鉴定提供了第一步。预测的蛋白显然与所有其他已报道的转化蛋白不同，但可能与src家族的成员有非常远的亲缘关系。
The nucleotide sequence of v-rel, the oncogene carried by reticuloendotheliosis virus (REV), has been determined. The defective transforming genome REV arose through the insertion of v-rel (1415 nucleotides) into the env gene of the helper virus REV-A. The predicted rel protein (503 amino acids) employs the REV-A env initiator and terminates within the p20E region of env. Because there are no natural antisera that detect the REV transforming protein, this nucleotide sequence provides the first step toward its isolation and characterization. The predicted protein is clearly distinct from all other reported transforming proteins but may be very distantly related to members of the src family.