Sonneradon A Extends Lifespan of Caenorhabditis elegans by Modulating Mitochondrial and IIS Signaling Pathways.
Sonneradon A Extends Lifespan of Caenorhabditis elegans by Modulating Mitochondrial and IIS Signaling Pathways.
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Sonneradon A 通过调节线粒体和 IIS 信号通路延长秀丽隐杆线虫的寿命
DOI：
10.3390/md20010059
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发表时间：
2022-01-08
期刊：
影响因子：
5.4
通讯作者：
Yi XX
中科院分区：
文献类型：
--
作者：
Jiang S;Jiang CP;Cao P;Liu YH;Gao CH;Yi XX
衰老与人类整体功能下降和各种与年龄相关的疾病风险增加有关。桑拿甲素(Sonneradon A，SDA)是从红树无瓣海桑果实中首次提取的一种新化合物，具有显著的抗衰老活性。然而，SDA在抗衰老中的作用尚不清楚。本文利用秀丽隐杆线虫动物模型，研究了SDA的抗衰老作用。结果表明，SDA可抑制ROS的产生53%，并减少脂质和脂褐素等衰老标志物的积累。此外，SDA还能增强机体对铜绿假单胞菌感染的天然免疫应答。对一系列突变体的遗传分析表明，SDA延长了Eat-2和GLP-1突变体的寿命。综上所述，这种作用可能与线粒体和胰岛素/胰岛素样生长因子-1信号转导通路增强对氧化应激的抵抗力有关。本研究结果为SDA在线虫中的抗衰老作用提供了新的证据，也为SDA在高等生物中的抗衰老作用提供了新的见解。
Aging is related to the lowered overall functioning and increased risk for various age-related diseases in humans. Sonneradon A (SDA), a new compound first extracted from the edible fruits of mangrove Sonneratia apetala, showed remarkable antiaging activity. However, the role of SDA in antiaging remains unclear. In this article, we studied the function of SDA in antiaging by using the animal model Caenorhabditis elegans. Results showed that SDA inhibited production of reactive oxygen species (ROS) by 53%, and reduced the accumulation of aging markers such as lipids and lipofuscins. Moreover, SDA also enhanced the innate immune response to Pseudomonas aeruginosa infection. Genetic analysis of a series of mutants showed that SDA extended the lifespan of the mutants of eat-2 and glp-1. Together, this effect may be related to the enhanced resistance to oxidative stress via mitochondrial and insulin/insulin-like growth factor-1 signaling (IIS) pathways. The results of this study provided new evidence for an antiaging effect of SDA in C. elegans, as well as insights into the implication of antiaging activity of SDA in higher organisms.
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影响因子：
8.8
作者：
Dhondt I;Petyuk VA;Cai H;Vandemeulebroucke L;Vierstraete A;Smith RD;Depuydt G;Braeckman BP
通讯作者：
Braeckman BP
影响因子：
28.3
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通讯作者：
Paludan, Soren R.
影响因子：
7.8
作者：
Ewald CY;Marfil V;Li C
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影响因子：
9.8
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通讯作者：
Gems D
影响因子：
7.8
作者：
Galimov, Evgeniy R.;Gems, David
通讯作者：
Gems, David