Self-reported marijuana use over 25years and abdominal adiposity: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
Self-reported marijuana use over 25years and abdominal adiposity: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
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DOI：
10.1111/add.14097
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发表时间：
2018-04-01
期刊：
影响因子：
6
通讯作者：
Schreiner, Pamela J.
中科院分区：
文献类型：
--
作者：
Bancks, Michael P.;Auer, Reto;Schreiner, Pamela J.
目的我们调查了累积寿命和当前大麻使用与中年时腹部总脂肪组织（AT）、内脏AT、皮下AT、肌间AT和平均肝脏衰减（LA）之间的关联。设计：对年轻人冠状动脉风险发展（CARDIA）研究参与者的纵向和横断面二级数据进行分析。在阿拉巴马州伯明翰、伊利诺伊州芝加哥、明尼苏达州明尼阿波利斯和美国加利福尼亚州奥克兰设立CARDIA现场中心。参与者：1985-1986年年龄在18-30岁之间，2010-2011年参加临床检查的心脏病参与者（n = 2902）。在25年的8次心脏检查中，根据对自填问卷的回答评估了大麻的使用情况，确定为累积大麻年数和当前使用状态。2010-2011年获得腹部非造影计算机断层扫描成像。在2010-2011年，84%的参与者报告了大麻使用史，11%的人报告在过去30天内使用过大麻。在调整之前，我们观察到更大的累积大麻使用与较低的总腹部和皮下AT体积和较低的LA相关，当前大麻使用与较低的皮下AT相关。然而，在调整了年龄，性别，种族，场地中心，香烟包年和当前使用，定期饮酒，累积饮酒年和体育活动后，无论是累积大麻使用还是当前使用都与任何腹部脂肪库无关。我们的估计值没有因年龄、性别或种族而异，也没有考虑队列损耗后的差异。结论：无论是累积使用大麻还是目前使用大麻，都与中年时的腹部、内脏、皮下或肌间脂肪组织或肝脏衰减无关。
Aims We investigated the association between cumulative lifetime and current marijuana use with total abdominal adipose tissue (AT), visceral AT, subcutaneous AT, intermuscular AT, and mean liver attenuation (LA) at mid-life. Design Longitudinal and cross-sectional secondary data analysis of participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Setting CARDIA field centers in Birmingham, AL; Chicago, IL; Minneapolis, MN; and Oakland, CA, USA. Participants CARDIA participants, aged 18-30 years in 1985-1986, who were present at the clinic examination in 2010-2011 (n = 2902). Measurements Marijuana use was assessed from responses to self-administered questionnaires at 8 CARDIA examinations over 25 years, determined as cumulative marijuana-years and current use status. Non-contrast computed tomography imaging of the abdomen was obtained in 2010-2011. Findings In 2010-2011, 84% of participants reported a history of marijuana use with 11% reporting use within the past 30 days. Before adjustment, we observed greater cumulative marijuana use was associated with lower total abdominal and subcutaneous AT volume and lower LA and current marijuana use was associated with lower subcutaneous AT. However, after adjustment for age, sex, race, field center, cigarette pack-years and current use, regular alcohol consumption, cumulative drink-years, and physical activity, neither cumulative marijuana use nor current use showed an association with any abdominal adipose depot. Our estimates did not differ by age, sex, or race nor after accounting for cohort attrition. Conclusion Neither cumulative marijuana use nor current marijuana use is associated with total abdominal, visceral, subcutaneous, or intermuscular adipose tissue, or liver attenuation in mid-life.