Radioactive iodine: An unappreciated threat to salivary gland function.
Radioactive iodine: An unappreciated threat to salivary gland function.
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DOI：
10.1111/odi.12774
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发表时间：
2018-03
期刊：
影响因子：
3.8
通讯作者：
Sunavala-Dossabhoy G
中科院分区：
文献类型：
--
作者：
Sunavala-Dossabhoy G
甲状腺癌是一种内分泌恶性肿瘤，其患病率在美国呈上升趋势。据估计，2017年将有近5.7万例甲状腺癌新病例被诊断出来。分化型甲状腺癌的标准治疗是甲状腺切除术，然后用高剂量放射性碘消融甲状腺残余（131I）。除甲状腺外，131I还会积聚在唾液腺细胞中，影响唾液腺的功能。因此，口干症是患者的一种常见且持续的主诉。尽管采取了标准的预防措施，实质损害和慢性唾液功能障碍仍在相当数量的患者中观察到。唾液对口腔内稳态很重要，唾液的减少会增加口腔疾病的风险。分化型甲状腺癌患者生存率高，因此保留唾液腺功能具有重要意义。专注于保持或恢复长期唾液流动的治疗可以显著提高甲状腺癌幸存者的生活质量。
Thyroid cancer is an endocrine malignancy whose prevalence is increasing in the United States. Nearly 57,000 new cases of thyroid cancer are estimated to be diagnosed in 2017. The standard of care for differentiated thyroid cancer is thyroidectomy followed by ablation of thyroid remnants with high-dose radioactive iodine (131I). Apart from thyroid glands, 131I accumulates in cells of salivary glands and compromises its function. Xerostomia is, therefore, a frequent and often persistent complaint of patients. Despite adoption of standard preventive measures, parenchymal damage and chronic salivary dysfunction are observed in a substantial number of patients. Saliva is important for oral homeostasis, and its reduction increases the risk of oral morbidity. As differentiated thyroid cancer patients have an excellent survival rate, preservation of salivary gland function carries added significance. A focus on treatments that preserve or restore long-term salivary flow can significantly improve the quality of life of thyroid cancer survivors.
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影响因子：
6.6
作者：
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通讯作者：
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DOI：
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