Fibroblast growth factor 6 regulates sizing of the muscle stem cell pool.
Fibroblast growth factor 6 regulates sizing of the muscle stem cell pool.
复制标题
成纤维细胞生长因子 6 调节肌肉干细胞库的大小。
DOI：
10.1016/j.stemcr.2021.10.006
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发表时间：
2021-12-14
影响因子：
5.9
通讯作者：
Lepper C
中科院分区：
文献类型：
--
作者：
Zofkie W;Southard SM;Braun T;Lepper C
骨骼肌干细胞，即，卫星细胞（SC）是损伤或慢性退行性肌病后骨骼肌再生的新肌核的重要来源。SC数量和再生能力在老化过程中减少。然而，控制初始SC池大小的分子调节剂是未知的。我们证明了成纤维细胞生长因子6（FGF6）对SC池缩放至关重要。缺乏FGF6的小鼠出生后早期来源的SC减少，再生受损。相反，在出生后早期增加FGF6足以使SC扩增。总之，这些数据支持FGF6是必要的，足以在关键的出生后时期调节SC数量，以建立静止的成体肌肉干细胞库。我们的工作强调了出生后发育作为一个时间窗口，通过生长因子信号传导，这可能是相关的设计新的生物医学策略，以提高组织再生的体干细胞群体接受。FGF6在出生后早期发育过程中调节肌肉干细胞池大小FGF6对于调节肌肉干细胞数量是必要的和足够的出生后早期对于体干细胞群体的缩放是可接受的在缺乏Fgf6的小鼠中肌肉干细胞和再生能力降低在这篇文章中，Lepper及其同事表明，成纤维细胞生长因子6（FGF6）是骨骼肌干细胞库缩放的分子调节因子。缺乏Fgf6的小鼠肌肉干细胞减少，肌肉再生受损。相反，在出生后早期增加FGF6会导致肌肉干细胞库的扩大。
Skeletal muscle stem cells, i.e., satellite cells (SCs), are the essential source of new myonuclei for skeletal muscle regeneration following injury or chronic degenerative myopathies. Both SC number and regenerative capacity diminish during aging. However, molecular regulators that govern sizing of the initial SC pool are unknown. We demonstrate that fibroblast growth factor 6 (FGF6) is critical for SC pool scaling. Mice lacking FGF6 have reduced SCs of early postnatal origin and impaired regeneration. By contrast, increasing FGF6 during the early postnatal period is sufficient for SC expansion. Together, these data support that FGF6 is necessary and sufficient to modulate SC numbers during a critical postnatal period to establish the quiescent adult muscle stem cell pool. Our work highlights postnatal development as a time window receptive for scaling a somatic stem cell population via growth factor signaling, which might be relevant for designing new biomedical strategies to enhance tissue regeneration. FGF6 regulates muscle stem cell pool sizing during early post-natal development FGF6 is both necessary and sufficient for modulating muscle stem cell number Early post-natal period is receptive for scaling of a somatic stem cell population Muscle stem cells and regenerative capacity are reduced in mice lacking Fgf6 In this article, Lepper and colleagues show that fibroblast growth factor 6 (FGF6) is a molecular regulator for skeletal muscle stem cell pool scaling. Fgf6-deficient mice have reduced muscle stem cells and compromised muscle regeneration. By contrast, increasing FGF6 during the early postnatal period leads to an expansion of the muscle stem cell pool.
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影响因子：
1.5
作者：
Lepper, Christoph;Fan, Chen-Ming
通讯作者：
Fan, Chen-Ming
影响因子：
4.6
作者：
Lepper, Christoph;Partridge, Terence A.;Fan, Chen-Ming
通讯作者：
Fan, Chen-Ming
影响因子：
5.2
作者：
Collins, Charlotte A.;Zammit, Peter S.;Partridge, Terence A.
通讯作者：
Partridge, Terence A.
影响因子：
--
作者：
ONTELL, M;FENG, KC;TAYLOR, F
通讯作者：
TAYLOR, F
影响因子：
3.2
作者：
Kästner, S;Elias, MC;Yablonka-Reuveni, Z
通讯作者：
Yablonka-Reuveni, Z