Review: In vivo models for measuring placental glutatione-S-transferase (GST-P 7-7) levels: a suitable biomarker for understanding cancer pathogenesis.
Review: In vivo models for measuring placental glutatione-S-transferase (GST-P 7-7) levels: a suitable biomarker for understanding cancer pathogenesis.
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综述：测量胎盘谷胱甘肽-S-转移酶 (GST-P 7-7) 水平的体内模型：了解癌症发病机制的合适生物标志物。
作者：
J. Noguti;L. F. Barbisan;A. Cesar;Camilo Dias Seabra;R. Choueri;D. Ribeiro
谷氨酸- s -转移酶（GSTs）包括一个与细胞解毒密切相关的酶家族。gst以同二聚体或异二聚体的形式存在，并被分为至少七个不同的类别。gst的主要功能是催化还原性谷胱甘肽（GSH）与广泛的潜在毒性和致癌性化合物的亲电位点结合，从而降低这些化合物的危险性并使其能够立即排出体外。胎盘GST，称为GST- p7 -7，是在正常胎盘组织中发现的主要亚型，占该组织中总GST浓度的67%。在发育过程中，gst - p7 -7的浓度降低，在成人组织中不存在。有趣的是，在几个实验测试系统中，gst - p7 -7在暴露于致癌物质后的成人组织中被检测到表达，被认为是致癌早期暴露和易感性的可靠生物标志物。在本文中，我们回顾了一系列涉及gst - p7 -7表达的研究，以了解癌症发病机制，特别是癌症风险。
The Glutatione-S-transferases (GSTs) comprise a family of enzymes closely associated with the cell detoxification of xenobiotics. GSTs exist as homo- or heterodimers and have been grouped into at least seven distinct classes. The main function of GSTs is to catalyze the conjugation of reduced glutathione (GSH) to an electrophilic site of a broad range of potentially toxic and carcinogenic compounds, thereby making such compounds less dangerous and enabling their ready-excretion. Placental GST, known as GST-P 7-7, is the main isoform found in normal placental tissue and comprises 67% of the total GST concentration in this tissue. During development, GST-P 7-7 decreases in concentration and is absent in adult tissues. Interestingly, GST-P 7-7 expression has been detected in adult tissues after exposure to carcinogenic agents in several experimental test systems, being considered a reliable biomarker of exposure and susceptibility in early phases of carcinogenesis. In this article, we review a series of studies involving GST-P 7-7 expression as a suitable tool for understanding cancer pathogenesis, especially cancer risk.