Genetic and Environmental Influences on the Handedness and Footedness in Japanese Twin Children
Genetic and Environmental Influences on the Handedness and Footedness in Japanese Twin Children
复制标题
遗传和环境对日本双胞胎儿童的手足习惯的影响
DOI：
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发表时间：
2005
影响因子：
0.9
通讯作者：
S. Ooki
中科院分区：
文献类型：
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作者：
S. Ooki
摘要本研究的目的是利用日本最大的双胞胎数据库之一，研究儿童时期惯用手和惯用脚的遗传贡献。受试者为1131对双胞胎，男1057人，女1205人，年龄为11或12岁（日本教育系统中学6年级）。所有数据均通过问卷调查收集。左（非右）利手的患病率在男性中为15%，在女性中为13%。男性左脚（非右脚）的患病率为13%，女性为11%。通过一致率和四项相关性估计的双胞胎之间的相似性表明，男性利手有轻微的遗传效应，女性利手没有遗传效应，两种性别的footedness也没有遗传效应。结构方程模型显示，小的遗传因素（11%）在男性利手和女性利手没有遗传因素。至于足型，在两种性别中均未观察到遗传因素。非共享的环境因素的影响是大的（85%），男性和中度（44%）的女性。此外，无论性别如何，利手和利足倾向于一致，多区相关性超过r = 0.70。双变量遗传分析的结果不一定令人满意。对于男性，无模型拟合。对于女性来说，共享和非共享的环境因素解释了利手和利脚的一致性。得出的结论是，遗传效应的利手和足是相对较小的，因为它们的协会;此外，相当大的双胞胎样本需要获得稳定和适当的结果。
Abstract The purpose of this study was to examine the genetic contribution to handedness and footedness in childhood using one of the largest available databases of Japanese twins. The participants were 1131 twin pairs, 1057 males and 1205 females, of 11 or 12 years of age (6th grade of secondary school in the Japanese education system). All data were gathered by questionnaire. The prevalence of left (nonright) handedness was 15% in males and 13% in females. The prevalence of left (nonright) footedness was 13% in males and 11% in females. The similarities between twin pairs, estimated by concordance rates and tetrachoric correlations, suggested a slight genetic effect on male handedness, no genetic effect on female handedness, and no genetic effect on footedness in either sex. Structural equation modeling showed small genetic factors (11%) in male handedness and no genetic factors in female handedness. As to footedness, no genetic factors were observed in either sex. The effects of nonshared environmental factors were large (85%) in males and moderate (44%) in females. Moreover, handedness and footedness tended to be concordant irrespective of sex, with polychoric correlations over r = .70. The results of bivariate genetic analyses were not necessarily satisfactory. For males, no model fit. For females, shared and nonshared environmental factors explained the concordance of handedness and footedness. It was concluded that the genetic effects on handedness and footedness are relatively small, as is their association; moreover, considerably large twin samples are needed to obtain stable and appropriate results.