RELATIONSHIP BETWEEN COLONIAL MORPHOLOGY AND ADHERENCE OF STREPTOCOCCUS-PNEUMONIAE
RELATIONSHIP BETWEEN COLONIAL MORPHOLOGY AND ADHERENCE OF STREPTOCOCCUS-PNEUMONIAE
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DOI：
10.1128/iai.63.3.757-761.1995
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发表时间：
1995-03-01
影响因子：
3.1
通讯作者：
TUOMANEN, EI
中科院分区：
文献类型：
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作者：
CUNDELL, DR;WEISER, JN;TUOMANEN, EI
肺炎球菌菌落混浊的时相变异在幼鼠鼻咽部定植的能力不同。为了在细胞水平上解释这一观察结果，我们比较了混浊变体粘附于颊上皮细胞、II型肺细胞或血管内皮细胞以及代表这些位点的同源受体的糖缀合物的能力。相对于不透明变体，透明表型与增强的对颊细胞（类似于100%）及其受体的粘附相关。只有适度的差异，坚持（
Phase variants in colonial opacity of pneumococci differ in the ability to colonize the nasopharynx of infant rats. To explain this observation at a cellular level,,ve compared the ability of opacity variants to adhere to buccal epithelial cells, type II pneumocytes, or vascular endothelial cells and to the glycoconjugates that represent the cognate receptors at each of these sites. The transparent phenotype was associated with enhanced adherence to buccal cells (similar to 100%) and their receptor relative to that of the opaque variants. Only modest differences in adherence (