A 4-week repeated oral dose toxicity study of fucoidan from the Sporophyll of Undaria pinnatifida in Sprague-Dawley rats
A 4-week repeated oral dose toxicity study of fucoidan from the Sporophyll of Undaria pinnatifida in Sprague-Dawley rats
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DOI：
10.1016/j.tox.2009.11.007
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发表时间：
2010-01-12
期刊：
影响因子：
4.5
通讯作者：
Lee, Boo-Yong
中科院分区：
文献类型：
--
作者：
Kim, Kui-Jin;Lee, Ok-Hwan;Lee, Boo-Yong
褐藻多糖是从褐藻中提取的，具有抗凝血、抗血栓、抗肿瘤和抗病毒活性。然而，对岩藻糖聚糖的毒理学尚未进行详细的研究。我们对褐藻多糖在Sprague-Dawley大鼠体内的毒性进行了测试。褐藻糖聚糖（1350 mg/kg bw/天，持续4周）在性别匹配的组中，在体重、眼科检查、尿液分析、血液学和组织病理学方面没有统计学上的显著差异。岩藻多糖没有改变凝血酶原时间或激活部分凝血活酶时间，表明不能改变血液凝固。该研究表明，在这种给药模式下，岩藻糖聚糖没有毒性。2009爱思唯尔爱尔兰有限公司版权所有。
Fucoidan is extracted from brown seaweeds, which can have anti-coagulant, antithrombotic, antitumor, and antiviral activities. However, detailed studies on the toxicology of fucoidan have not been performed. Here we tested the toxicity of fucoidan in Sprague-Dawley rats. Fucoidan (1350 mg/kg bw/day for 4 weeks) did not induce statistically significant differences in groups matched by gender with respect to body weight, ophthalmoscopy, urinalysis, hematology, and histopathology. Fucoidan did not change prothrombin time or activated partial thromboplastin time, indicating an inability to change blood clotting. This study demonstrated that fucoidan is not toxic under this administration paradigm. (C) 2009 Elsevier Ireland Ltd. All rights reserved.