PRESENCE AND ACTION OF ACETYLCHOLINE IN EXPERIMENTAL BRAIN TRAUMA
PRESENCE AND ACTION OF ACETYLCHOLINE IN EXPERIMENTAL BRAIN TRAUMA
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DOI：
10.1152/jn.1946.9.5.349
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发表时间：
1946-01-01
影响因子：
2.5
通讯作者：
BORNSTEIN, MB
中科院分区：
文献类型：
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作者：
BORNSTEIN, MB
以下实验。对狗和猫的脑震荡，其未消毒的脑脊液中乙酰胆碱（ACh）含量估计在2.7 9.0 [γ] %之间，持续时间长达48小时。行为模式和脑电图的改变也在创伤后持续了5天。以适当的削减部分取消。阿托品的剂量。当乙酰胆碱直接灌注于皮层时，在低生理关注下产生兴奋性或同步脑电图效应。[长折线]17 %以下，对高生理关注有抑制作用。[长破折号]2.7%或更多。脑内乙酰胆碱为0.02[长折线]10.0 [γ]，与创伤后观察到的脑电图和行为模式相似。这些也被阿托品废除了。提示“游离乙酰胆碱”可能是早期创伤后抑郁和兴奋状态的一个因素。
Following exptl. concussion to dogs and cats, the acetyl-choline (ACh) content of their uneserinized ecrebro-spinal-lluid was estimated to range from 2.7 9.0 [gamma] % and persisted for as long as 48 hrs. Patterned behavioral and EEG changes were also noted to persist for 5 days following trauma. These were partially abolished with appropriate subcut. doses of atropine. ACh, when perfused directly over the cortex, produced excitatory or synchronous EEG effects in low physiologic concn.[long dash]1 7 % or less and depressant effects in high physiologic concn.[long dash]2.0 7 % or more. Intracisternal ACh, 0.02[long dash]10.0 [gamma], produced similar EEG and behavioral patterns as observed following trauma. These also were abolished by atropine. It is suggested that "free ACh" may be a factor in early post-traumatic depressed and excitatory states.