Phosphorus dendrimers and photodynamic therapy. Spectroscopic studies on two dendrimer-photosensitizer complexes: Cationic phosphorus dendrimer with rose bengal and anionic phosphorus dendrimer with methylene blue
Phosphorus dendrimers and photodynamic therapy. Spectroscopic studies on two dendrimer-photosensitizer complexes: Cationic phosphorus dendrimer with rose bengal and anionic phosphorus dendrimer with methylene blue
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DOI：
10.1016/j.ijpharm.2015.06.014
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发表时间：
2015-08-15
影响因子：
5.8
通讯作者：
Klajnert-Maculewicz, Barbara
中科院分区：
文献类型：
--
作者：
Dabrzalska, Monika;Zablocka, Maria;Klajnert-Maculewicz, Barbara
树枝状大分子由于其独特的结构，在化疗、基因治疗以及近年来的光动力治疗等药物传递系统中发挥着重要作用。我们研究了两个树枝状大分子光敏剂系统的背景下，这些系统在光动力学治疗的潜在用途。用紫外-可见光谱法研究了第二代阴离子磷树枝状大分子与亚甲基蓝的混合物，用荧光光谱法研究了第三代阳离子磷树枝状大分子与玫瑰红的混合物。这两个系统的光谱分析揭示了通过静电相互作用以及p堆积的树枝状大分子光敏剂复合物的形成。玫瑰红-阳离子树枝状聚合物复合物的化学计量估计为7：1，亚甲基蓝-阴离子树枝状聚合物复合物的化学计量估计为9：1。这些结果表明，这些聚阴离子或聚阳离子磷树枝状大分子可以作为光动力学治疗的载体有前途的候选人。(C)2015 Elsevier B.V.版权所有。
Dendrimers due to their unique architecture may play an important role in drug delivery systems including chemotherapy, gene therapy and recently, photodynamic therapy as well. We investigated two dendrimer-photosensitizer systems in context of potential use of these systems in photodynamic therapy. The mixtures of an anionic phosphorus dendrimer of the second generation and methylene blue were studied by UV-vis spectroscopy while that of a cationic phosphorus dendrimer (third generation) and rose bengal were investigated by spectrofluorimetric methods. Spectroscopic analysis of these two systems revealed the formation of dendrimer-photosensitizer complexes via electrostatic interactions as well as p stacking. The stoichiometry of the rose bengal-cationic dendrimer complex was estimated to be 7:1 and 9:1 for the methylene blue-anionic dendrimer complex. The results suggest that these polyanionic or polycationic phosphorus dendrimers can be promising candidates as carriers in photodynamic therapy. (C) 2015 Elsevier B.V. All rights reserved.