Dlx1&2 and Mash1 Transcription Factors Control MGE and CGE Patterning and Differentiation through Parallel and Overlapping Pathways
Dlx1&2 and Mash1 Transcription Factors Control MGE and CGE Patterning and Differentiation through Parallel and Overlapping Pathways
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DOI：
10.1093/cercor/bhp045
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发表时间：
2009-07-01
期刊：
影响因子：
3.7
通讯作者：
Rubenstein, John L. R.
中科院分区：
文献类型：
--
作者：
Loug, Jason E.;Cobos, Inma;Rubenstein, John L. R.
在这里，我们定义了发育中的小鼠内侧和尾侧神经节隆起、基底神经节原基和套膜中间神经元的祖细胞和神经元中类似于100种转录因子（TF）的表达。我们已经开始阐明这些基因的转录层次相对于Dix同源结构域基因，这是必不可少的最γ-氨基丁酸能投射神经元的基底神经节的分化。该分析鉴定了Dlx依赖性和Dlx非依赖性途径。Dlx非依赖性途径部分取决于Mash 1碱性螺旋-环-螺旋（b-HLH）TF的功能。这些分析定义了核心转录组件，差异指定的苍白球，基底端脑，和苍白中间神经元的身份和分化。
Here we define the expression of similar to 100 transcription factors (TFs) in progenitors and neurons of the developing mouse medial and caudal ganglionic eminences, anlage of the basal ganglia and pallial interneurons. We have begun to elucidate the transcriptional hierarchy of these genes with respect to the Dix homeodomain genes, which are essential for differentiation of most gamma-aminobutyric acidergic projection neurons of the basal ganglia. This analysis identified Dlx-dependent and Dlx-independent pathways. The Dlx-independent pathway depends in part on the function of the Mash1 basic helix-loop-helix (b-HLH) TF. These analyses define core transcriptional components that differentially specify the identity and differentiation of the globus pallidus, basal telencephalon, and pallial interneurons.