Cardiovascular Disease Risk Factor Variables at the Preschool Age: The Bogalusa Heart Study
Cardiovascular Disease Risk Factor Variables at the Preschool Age: The Bogalusa Heart Study
复制标题
学龄前儿童心血管疾病危险因素变量：Bogalusa 心脏研究
作者：
G. Berenson;T. A. Foster;G. Frank;R. Frerichs;S. Srinivasan;A. Voors;L. Webber
作为描述动脉粥样硬化早期自然史研究的一部分，对714名2岁半至5岁半的儿童进行了检查。每个孩子的身高、体重、三头肌皮褶厚度、血压、血脂和脂蛋白，以及完整的体格检查。黑人儿童比白色儿童更高更重，但白人的三头肌皮褶更大。在三种仪器上获得的平均血压读数显示出不同的血压水平。Infrasonde给出的读数最低，而Baumanometer给出的读数最高，只有Infrasonde观察到了年龄梯度。多元回归分析表明，12%至22%的血压变异可以解释选定的自变量。血清总胆固醇、B-脂蛋白和A-脂蛋白水平在黑人男孩中略高于白色男孩。甘油三酯和前β-脂蛋白的情况正好相反。对于甘油三酯，观察到显著的种族和性别效应以及与体重相对于身高（W/H2）的关系。年龄和W/H2与前脂蛋白呈正相关。当学龄前儿童相比，我们以前研究的学龄人口，风险因素变量的相互作用的大小往往会随着年龄的增长而增加，这表明环境因素往往会产生越来越大的影响。
SUMMARYAs part of a study to describe the early natural history of atherosclerosis, 714 children, 2'/2 to 51/2 years of age, were examined. Height, weight, triceps skinfold, blood pressure, serum lipids and lipoproteins, and a complete physical examination were obtained on each child. Black children were both taller and heavier than white children, but triceps skinfolds were greater for whites. Mean blood pressure readings obtained on each of three instruments showed different levels of blood pressure. The Infrasonde gave the lowest readings while the Baumanometer gave the highest, and an age gradient was observed only for the Infrasonde. Multiple regression analysis indicated that 12% to 22% of the variability of blood pressure could be explained by selected independent variables. Serum levels of total cholesterol,B-lipoproteins and a-lipoproteins were slightly higher in black boys than white boys. The reverse was true for triglycerides and pre-3-lipoproteins. For triglycerides, significant racial and sex effects and a relationship with weight relative to height (W/H2) were noted. Age and W/H2 were positively associated with pre-fl-lipoproteins. When the preschool-aged children are compared to our previously studied school-aged population, the magnitude of the interaction of the risk factor variables tends to increase with age, suggesting that environmental factors tend to exert an increasing effect.