Animal models of painful diabetic neuropathy: the STZ rat model.
Animal models of painful diabetic neuropathy: the STZ rat model.
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DOI：
10.1002/0471142301.ns0918s29
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发表时间：
2004-11-01
影响因子：
--
通讯作者：
Morrow, Thomas J
中科院分区：
文献类型：
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作者：
Morrow, Thomas J
疼痛性周围神经病变是糖尿病常见的继发性并发症。链脲佐菌素（STZ）诱导的糖尿病大鼠是研究疼痛性糖尿病神经病变机制和评估潜在治疗方法最常用的动物模型。描述了一种低剂量STZ诱导大鼠实验性糖尿病的方案。本文描述了几种行为学分析方法，这些方法通常用于评估糖尿病动物模型中神经性疼痛的不同方面，包括机械异常性疼痛和热痛觉过敏。
Painful peripheral neuropathy is a common secondary complication of diabetes. The streptozotocin (STZ)-induced diabetic rat is the most commonly employed animal model used to study mechanisms of painful diabetic neuropathy and to evaluate potential therapies. A low dose STZ protocol is described for inducing experimental diabetes in the rat. Several behavioral assays are described, which are routinely used to assess different aspects of neuropathic pain in this animal model of diabetes mellitus, including mechanical allodynia and heat hyperalgesia.