Contractile responses to sympathetic activation after coronary instrumentation.
Contractile responses to sympathetic activation after coronary instrumentation.
复制标题
冠状动脉植入术后交感神经激活的收缩反应。
DOI：
10.1152/ajpheart.1987.252.6.h1059
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
RossJr,J
中科院分区：
文献类型：
--
作者：
Heusch,G;Guth,BD;Roth,DM;Seitelberger,R;RossJr,J
在狗中检查了急性冠状动脉夹层和慢性冠状动脉器械对交感神经激活的收缩反应的后果。在7只麻醉犬急性解剖左回旋支冠状动脉（CX）后，刺激左腹外侧颈心神经不会改变收缩期缩短速度的增加。急性左冠状动脉前降支（LAD）夹层后，神经刺激增加缩短速度的后壁在所有的狗，但增强前壁的只有5只狗。在6只清醒的狗慢性器械的CX，反射性交感神经激活引起的下腔静脉闭塞，增加增厚速度的前壁和后壁都在1和3周后仪器。在其他六只狗与慢性仪器的前降支，腔静脉闭塞的反应是不均匀的，与交感神经支配的形态程度。因此，LAD的急性夹层和慢性器械可能导致交感神经去神经，但不会导致CX区域功能显著的交感神经去神经。
The consequences of acute coronary dissection and chronic coronary instrumentation on contractile responses to sympathetic activation were examined in dogs. Stimulation of the left ventrolateral cervical cardiac nerve in seven anesthetized dogs after acute dissection of the left circumflex coronary artery (CX) did not change the increase in systolic shortening velocity. After acute dissection of the left anterior descending coronary artery (LAD), nerve stimulation increased shortening velocity of the posterior wall in all dogs but enhanced that of the anterior wall in only five dogs. In six conscious dogs with chronic instrumentation of the CX, reflex sympathetic activation induced by occlusion of the inferior vena cava comparably increased thickening velocities of both the anterior wall and posterior walls both at 1 and 3 wk after instrumentation. In six other dogs with chronic instrumentation of the LAD, responses to caval occlusion were nonuniform and correlated to the morphological degree of sympathetic denervation. Therefore, acute dissection and chronic instrumentation of the LAD may produce sympathetic denervation but do not cause functionally significant sympathetic denervation of the CX region.