Nutritional regulation of gene expression
Nutritional regulation of gene expression
复制标题
DOI：
10.1016/s0002-9343(98)00342-8
复制
发表时间：
1999-01-25
影响因子：
5.9
通讯作者：
Cousins, Robert J.
中科院分区：
文献类型：
--
作者：
Cousins, Robert J.
基因受影响转录速率的复杂反应元件阵列的调节。营养素和激素要么直接影响这些速率，要么通过专门的信号通路间接作用。维生素A和D、脂肪酸、某些固醇和锌的代谢是直接影响转录的营养素。膳食纤维的成分可以通过改变激素信号、机械刺激和肠道微生物菌群产生的代谢物来间接影响基因表达。此外，水溶性纤维的消耗可能导致通过影响转录速率的间接机制介导的基因表达的变化。在大肠中，短链脂肪酸，包括丁酸，由微生物产生。丁酸可以间接影响基因表达。一些纤维来源限制营养吸收，特别是微量元素。这可能对基因表达产生直接或间接的影响。确定结肠上皮细胞中受膳食纤维差异调节的基因将是理解饮食因素在结直肠癌进展中作用的重要一步。
Genes are regulated by complex arrays of response elements that influence the rate of transcription. Nutrients and hormones either act directly to influence these rates or act indirectly through specialized signaling pathways. Metabolites of vitamins A and D, fatty acids, some sterols, and zinc are among the nutrients that influence transcription directly. Components of dietary fiber may influence gene expression indirectly through changes in hormonal signaling, mechanical stimuli, and metabolites produced by the intestinal microflora. In addition, consumption of water-soluble fibers may lead to changes in gene expression mediated through indirect mechanisms that influence transcription rates. In the large intestine, short-chain fatty acids, including butyric acid, are produced by microflora. Butyric acid can indirectly influence gene expression. Some sources of fiber limit nutrient absorption, particularly of trace elements. This could have direct or indirect effects on gene expression. Identification of genes in colonic epithelial cells that are differentially regulated by dietary fiber will be an important step toward understanding the role of dietary factors in colorectal cancer progression.