Association of the interleukin-6 polymorphisms with systemic lupus erythematosus: a meta-analysis
Association of the interleukin-6 polymorphisms with systemic lupus erythematosus: a meta-analysis
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DOI：
10.1177/0961203315588971
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发表时间：
2015-10-01
期刊：
影响因子：
2.6
通讯作者：
Meng, W.
中科院分区：
文献类型：
--
作者：
Cui, Y. X.;Fu, C. W.;Meng, W.
背景白细胞介素（IL）-6是一种重要的促炎细胞因子，在系统性红斑狼疮（SLE）的发病中起着重要的作用。IL-6基因多态性与SLE的关系目前尚无定论。方法检索PubMed和Web of Science数据库，数据更新至2014年8月30日。采用等位基因对比、显性、隐性和纯合子对比模型进行Meta分析。结果IL-6-174 G/C多态性在除纯合子对照模型外的所有模型下的分析均表明在总体人群中存在关联（等位基因对比模型：比值比（OR）1.428，95%可信区间（CI）1.124-1.812，显性模型：OR 1.382，95% CI 1.037-1.842，隐性模型：OR 1.610，95%CI 1.158-2.240，纯合子对照模型：OR 1.759，95%CI 0.989-3.127），以及在所有四种遗传模型下的欧洲个体中（等位基因对照模型：OR 1.557，95%CI 1.155-2.098，显性模型：OR 1.699，95%CI 1.203-2.400，隐性模型：OR 1.506，95%CI 1.176-1.930，纯合子对照模型：OR 2.118，95% CI 1.103-4.065）。对IL-6-572 G/C多态性的分析表明，在隐性模型下，总体种族之间存在显著关联（OR 1.491，95%CI 1.104-2.014），但在其他模型下或亚洲个体中不存在显著关联。此外，IL-6-174 G/C多态性与盘状皮损和抗核抗体（ANA）分别在等位基因对比模型和隐性模型下存在显著关联（盘状皮肤病变：OR 2.271，95% CI 1.053-4.895; ANA：结论IL-6基因多态性与SLE发病风险相关，提示IL-6-174 G/C和IL-6-572 G/C多态性可能与SLE易感性有关。
Background Interleukin (IL)-6, an important proinflammatory cytokine, plays a potential pathological role in systemic lupus erythematosus (SLE). Studies on the relationship of IL-6 gene polymorphisms with SLE are inconclusive. The aim of this study was to estimate the relationship more precisely.Methods The databases of PubMed and Web of Science updated to 30 August 2014 were retrieved. Meta-analysis was conducted using allelic contrast, dominant, recessive and homozygote contrast models. Fifteen studies were included in this study and ethnicity-specific meta-analysis was performed on European, Iranian and Asian populations.Results Analysis for the IL-6-174 G/C polymorphism under all models except the homozygote contrast model indicated an association in the overall population (allelic contrast model: odds ratio (OR) 1.428, 95% confidence interval (CI) 1.124-1.812, dominant model: OR 1.382, 95% CI 1.037-1.842, recessive model: OR 1.610, 95% CI 1.158-2.240, homozygote contrast model: OR 1.759, 95% CI 0.989-3.127), as well as in European individuals under all four genetic models (allelic contrast model: OR 1.557, 95% CI 1.155-2.098, dominant model: OR 1.699, 95% CI 1.203-2.400, recessive model: OR 1.506, 95% CI 1.176-1.930, homozygote contrast model: OR 2.118, 95% CI 1.103-4.065). Analysis for the IL-6-572 G/C polymorphism indicated significant association in overall ethnicities under the recessive model (OR 1.491, 95% CI 1.104-2.014), but not under other models or in Asian individuals. In addition, significant association between the IL-6-174 G/C polymorphism and discoid skin lesions and antinuclear antibodies (ANAs) were found under the allelic contrast model and recessive model, respectively (discoid skin lesions: OR 2.271, 95% CI 1.053-4.895; ANAs: OR 2.244, 95% CI 1.141-4.416).Conclusion This meta-analysis provides evidence of the association between the IL-6 polymorphism and the risk of SLE, hinting that the IL-6-174 G/C and IL-6-572 G/C polymorphisms may play a role in SLE susceptibility.