QUANTITATIVE TOPOGRAPHIC CURVATURE MAPS OF THE POSTERIOR EYE UTILIZING OPTICAL COHERENCE TOMOGRAPHY.
QUANTITATIVE TOPOGRAPHIC CURVATURE MAPS OF THE POSTERIOR EYE UTILIZING OPTICAL COHERENCE TOMOGRAPHY.
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使用光学相干断层扫描的后眼的定量地形曲率图。
DOI：
10.1097/iae.0000000000002897
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发表时间：
2021-04-01
期刊：
影响因子：
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通讯作者：
Kuo AN
中科院分区：
文献类型：
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作者：
McNabb RP;Liu AS;Gospe SM 3rd;El-Dairi M;Meekins LC;James C;Vann RR;Izatt JA;Kuo AN
视网膜的变形，例如近视中的葡萄肿或高颅内压中的巩膜扁平化，可以具有挑战性地用正面成像来量化。我们描述了一种基于OCT的方法，用于生成正常和病理眼的定量后眼地形图。利用“全眼”OCT，我们校正了受试者的光学畸变，以生成空间准确的后眼OCT体积，并为每个同意的受试者创建局部曲率（KM，mm-1）地形图。我们对9名受试者进行了成像，其中3名正常，2名患有近视变性（MD），4名患有视神经乳头水肿，包括1名纵向成像。正常受试者的平均颞侧KM为0.0923 mm−1，鼻侧KM为0.0927 mm−1，KM局部变异性为0.0162 mm−1。在MD受试者中，KM局部变异性较高，为0.0836 mm−1。在视神经乳头水肿患者中，鼻KM比颞KM更平坦（0.0709 mm−1 vs. 0.0885 mm−1）。所有受试者的平均会话内KM重复性为0.0036 mm−1。我们开发了一种基于OCT的定量后眼部地形图方法，该方法能够以微米级分辨率分析局部曲率，并有可能帮助临床医生和研究人员更早地描述患者的细微局部视网膜变形，并随时间推移跟踪其发展。我们开发了一种基于OCT的定量后眼部地形图方法，该方法能够以微米级分辨率分析局部曲率，并有可能帮助临床医生和研究人员更早地描述患者的细微局部视网膜变形，并随时间推移跟踪其发展。
Deformations of the retina such as staphylomas in myopia or scleral flattening in high intracranial pressure can be challenging to quantify with en face imaging. We describe an OCT based method for the generation of quantitative posterior eye topography maps in normal and pathologic eyes. Utilizing “whole eye” OCT we corrected for subjects’ optical distortions to generate spatially accurate posterior eye OCT volumes and created local curvature (KM, mm−1) topography maps for each consented subject. We imaged nine subjects, three normal, two with myopic degeneration (MD), and four with papilledema including one that was imaged longitudinally. Normal subjects mean temporal KM was 0.0923 mm−1, nasal KM was 0.0927 mm−1, and KM local variability was 0.0162 mm−1. In MD subjects KM local variability was higher at 0.0836 mm−1. In papilledema subjects nasal KM was flatter compared to temporal KM (0.0709 mm−1 vs. 0.0885 mm−1). Mean intrasession KM repeatability for all subjects was 0.0036 mm−1. We have developed an OCT based method for quantitative posterior eye topography that offers the ability to analyze local curvature with micron scale resolution and offers the potential to help clinicians and researchers characterize subtle, local retinal deformations earlier in patients and follow their development over time. We have developed an OCT based method for quantitative posterior eye topography that offers the ability to analyze local curvature with micron scale resolution and offers the potential to help clinicians and researchers characterize subtle, local retinal deformations earlier in patients and follow their development over time.