The exposome and liver disease - how environmental factors affect liver health.
The exposome and liver disease - how environmental factors affect liver health.
复制标题
麻烦和肝脏疾病-环境因素如何影响肝脏健康。
DOI：
10.1016/j.jhep.2023.02.034
复制
发表时间：
2023-08
影响因子：
25.7
通讯作者：
Coumoul, Xavier
中科院分区：
文献类型：
--
作者：
Barouki, Robert;Samson, Michel;Blanc, Etienne B.;Colombo, Massimo;Zucman-Rossi, Jessica;Lazaridis, Konstantinos N.;Miller, Gary W.;Coumoul, Xavier
关键词：
自最初的发展的干扰素组的概念，许多努力已经致力于通过分析，流行病学和毒理学/机制研究的干扰素组的特性。现在迫切需要将疾病组学与人类疾病联系起来，并将疾病组学与基因组学和其他组学一起纳入与环境相关的病理学的表征中。肝脏疾病特别适合此类研究，因为肝脏的主要功能包括检测，解毒和消除外源性物质以及炎症反应。众所周知，几种肝脏疾病与i）成瘾行为，如饮酒，吸烟，以及在一定程度上饮食不平衡和肥胖，ii）病毒和寄生虫感染，以及iii）暴露于毒素和职业化学品有关。最近的研究表明，环境暴露也与肝脏疾病密切相关，其中包括空气污染（颗粒物和挥发性化学品），污染物如多环芳烃，双酚A和全氟和多氟物质，以及物理应激源如辐射。此外，微生物代谢产物和“肠-肝”轴在肝脏疾病中起主要作用。暴露组学有望在肝脏病理学领域发挥重要作用。方法学的进步，如代谢组学框架，确定风险因素的基因组和表观基因组特征，以及跨物种生物途径分析，应进一步描述代谢组学对肝脏的影响，为改善预防开辟道路，以及识别暴露和影响的新生物标志物，以及其他治疗靶点。
Since the initial development of the exposome concept, much effort has been devoted to the characterisation of the exposome through analytical, epidemiological, and toxicological/mechanistic studies. There is now an urgent need to link the exposome to human diseases and to include exposomics in the characterisation of environment-linked pathologies together with genomics and other omics. Liver diseases are particularly well suited for such studies since major functions of the liver include the detection, detoxification, and elimination of xenobiotics, as well as inflammatory responses. It is well known that several liver diseases are associated with i) addictive behaviours such as alcohol consumption, smoking, and to a certain extent dietary imbalance and obesity, ii) viral and parasitic infections, and iii) exposure to toxins and occupational chemicals. Recent studies indicate that environmental exposures are also significantly associated with liver diseases, and these include air pollution (particulate matter and volatile chemicals), contaminants such as polyaromatic hydrocarbons, bisphenol A and per-and poly-fluorinated substances, and physical stressors such as radiation. Furthermore, microbial metabolites and the “gut-liver” axis play a major role in liver diseases. Exposomics is poised to play a major role in the field of liver pathology. Methodological advances such as the exposomics-metabolomics framework, the determination of risk factors’ genomic and epigenomic signatures, and cross-species biological pathway analysis should further delineate the impact of the exposome on the liver, opening the way for improved prevention, as well as the identification of new biomarkers of exposure and effects, and additional therapeutic targets.
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DOI：
10.1016/j.bbagrm.2016.02.013
发表时间：
2016-09
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Chai SC;Cherian MT;Wang YM;Chen T
通讯作者：
Chen T
影响因子：
4.6
作者：
Fader KA;Nault R;Zhang C;Kumagai K;Harkema JR;Zacharewski TR
通讯作者：
Zacharewski TR
肠道菌群失调与低剂量 PCB126 诱导的血脂异常和非酒精性脂肪肝相关
影响因子：
9.8
作者：
Chi, Yulang;Lin, Yi;Dong, Sijun
通讯作者：
Dong, Sijun
影响因子：
10.4
作者：
Duval C;Teixeira-Clerc F;Leblanc AF;Touch S;Emond C;Guerre-Millo M;Lotersztajn S;Barouki R;Aggerbeck M;Coumoul X
通讯作者：
Coumoul X
影响因子：
4.6
作者：
Fader, Kelly A.;Nault, Rance;Zacharewski, Timothy R.
通讯作者：
Zacharewski, Timothy R.