Fucoidan from seaweed Fucus vesiculosus inhibits 2,4-dinitrochlorobenzene-induced atopic dermatitis
Fucoidan from seaweed Fucus vesiculosus inhibits 2,4-dinitrochlorobenzene-induced atopic dermatitis
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来自海藻 Fucus vesiculosus 的岩藻依聚糖可抑制 2,4-二硝基氯苯诱导的特应性皮炎。
DOI：
10.1016/j.intimp.2019.105823
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发表时间：
2019-10-01
影响因子：
5.6
通讯作者：
Ji, Minjun
中科院分区：
文献类型：
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作者：
Tian, Tian;Chang, Hao;Ji, Minjun
岩藻依聚糖硫酸酯是A类清道夫受体（SR-A）的激活剂，具有抗炎、抗氧化、抗肿瘤等多种生物活性。然而，岩藻依聚糖对特应性皮炎（AD）的影响尚未阐明。为了评估这一点，2，4-二硝基氟苯（DNFB）处理的BALB/c小鼠涂有岩藻依聚糖。结果表明，褐藻糖胶能明显改善耳肿胀，改善腹部皮肤病变，减少炎症细胞浸润。此外，褐藻多糖硫酸酯显着抑制DNFB诱导的AD小鼠的血清IgE和IL-4水平。岩藻多糖治疗的AD小鼠皮损和脾脏中的CD 4（+）T细胞浸润也减少。此外，褐藻糖胶治疗促进Treg细胞，但减弱了DNFB诱导的AD小鼠脾脏中的Th 1/17应答。总之，这些结果表明，岩藻依聚糖，一种天然海藻富含的多糖，在治疗AD中具有潜在的治疗功效，与通过诱导Treg细胞诱导更高的抗炎反应相关。
Fucoidan, one activator of scavenger receptor class A (SR-A), plays important roles in a variety of biological activities, including anti-inflammatory, antioxidant, and antitumor actions. However, the effects of fucoidan on atopic dermatitis (AD) have not been elucidated. To assess this, 2,4-dinitrofluorobenzene (DNFB)-treated BALB/c mice were painted with fucoidan. Results showed that fucoidan significantly ameliorated ear swelling, improved abdomen skin lesions, and decreased inflammatory cell infiltration. In addition, fucoidan significantly suppressed the serum levels of IgE and IL-4 in DNFB-induced AD mice. The infiltration of CD4(+) T cells in skin lesions and spleen was also reduced in fucoidan-treated AD mice. Furthermore, treatment with fucoidan promoted Treg cells but attenuated Th1/17 response in the spleens from DNFB-induced AD mice. Together, these results suggest that fucoidan, a natural seaweed-rich polysaccharide, has a potential therapeutic efficacy in the treatment of AD, correlates with the induction of higher anti-inflammatory response through inducing Treg cells.