Inflammatory biomarkers and fatigue during radiation therapy for breast and prostate cancer.
Inflammatory biomarkers and fatigue during radiation therapy for breast and prostate cancer.
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DOI：
10.1158/1078-0432.ccr-08-2584
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发表时间：
2009-09-01
期刊：
影响因子：
--
通讯作者：
Aziz N
中科院分区：
文献类型：
--
作者：
Bower JE;Ganz PA;Tao ML;Hu W;Belin TR;Sepah S;Cole S;Aziz N
辐射引起的行为症状的生物标志物，如疲劳，尚未确定。在癌症幸存者中将炎症过程与疲劳联系起来的研究使我们验证了这样一个假设，即促炎细胞因子网络的激活与乳腺癌和前列腺癌放射治疗期间的疲劳症状相关。患有早期乳腺癌（n = 28）和前列腺癌（n = 20）的个体完成问卷调查，并提供血液样本，用于在放射治疗过程之前、期间和之后进行评估时测定血清白细胞介素1β（IL-1β）和IL-6水平。在一组受试者中检测促炎细胞因子活性的血清标志物，包括IL-1受体拮抗剂和C反应蛋白。随机系数模型用于评估细胞因子水平变化与疲劳之间的关联。正如预期的那样，放射治疗期间疲劳显著增加。血清炎症标志物C-反应蛋白和IL-1受体拮抗剂水平的变化与疲劳症状的增加呈正相关（P < 0.05），而血清IL-1β和IL-6水平与疲劳无关。在控制了潜在的生物行为混杂因素（包括年龄、体重指数、激素治疗、抑郁和睡眠障碍）的分析中，这些影响仍然显著（P < 0.05）。结果表明，促炎细胞因子网络的激活和促炎细胞因子活性的下游生物标志物的相关增加与乳腺癌和前列腺癌放射治疗期间的疲劳相关。
Biomarkers of radiation-induced behavioral symptoms, such as fatigue, have not been identified. Studies linking inflammatory processes to fatigue in cancer survivors led us to test the hypothesis that activation of the proinflammatory cytokine network is associated with fatigue symptoms during radiation therapy for breast and prostate cancer. Individuals with early-stage breast (n = 28) and prostate cancer (n = 20) completed questionnaires and provided blood samples for determination of serum levels of interleukin 1β (IL-1β) and IL-6 at assessments conducted before, during, and after a course of radiation therapy. Serum markers of proinflammatory cytokine activity, including IL-1 receptor antagonist and C-reactive protein, were examined in a subset of participants. Random coefficient models were used to evaluate the association between changes in cytokine levels and fatigue. As expected, there was a significant increase in fatigue during radiation treatment. Changes in serum levels of inflammatory markers C-reactive protein and IL-1 receptor antagonist were positively associated withincreases in fatigue symptoms (Ps < 0.05), although serum levels of IL-1β and IL-6 were not associated with fatigue. These effects remained significant (Ps < 0.05) in analyses controlling for potential biobehavioral confounding factors, including age, body mass index, hormone therapy, depression, and sleep disturbance. Results suggest that activation of the proinflammatory cytokine network and associated increases in downstream biomarkers of proinflammatory cytokine activity are associated with fatigue during radiation therapy for breast and prostate cancer.