The role of epistatic gene interactions in the response to selection and the evolution of evolvability
The role of epistatic gene interactions in the response to selection and the evolution of evolvability
复制标题
DOI：
10.1016/j.tpb.2005.05.002
复制
发表时间：
2005-11-01
影响因子：
1.4
通讯作者：
Hansen, TF
中科院分区：
文献类型：
--
作者：
Carter, AJR;Hermisson, J;Hansen, TF
有人认为基因型表型图的结构决定了进化性，但很少有研究试图量化这些影响。在本文中，我们使用多线性上位模型来研究不同形式的上位对方向选择响应的影响。我们对加性遗传方差的变化进行了分析预测，并使用基于个体的模拟来了解进化性的动态和遗传结构的进化。这表明加性方差演化以及可演化性的主要决定因素是方向上位性。正方向上位导致进化加速，而负方向上位导致管道化。相反，纯粹的非定向上位性对选择的反应几乎没有影响。其结果之一是经典的上位方差分量不区分方向性和非方向性效应，作为进化动力学的预测因子是无用的。连锁不平衡的建立也具有可以忽略不计的影响。我们认为，定向上位可能对进化动力学产生重大影响，应该成为上位实证研究的焦点。 (c) 2005 Elsevier Inc. 保留所有权利。
It has been argued that the architecture of the genotype phenotype map determines evolvability, but few studies have attempted to quantify these effects. In this article we use the multilinear epistatic model to study the effects of different forms of epistasis on the response to directional selection. We derive an analytical prediction for the change in the additive genetic variance, and use individual-based simulations to understand the dynamics of evolvability and the evolution of genetic architecture. This shows that the major determinant for the evolution of the additive variance, and thus the evolvability, is directional epistasis. Positive directional epistasis leads to an acceleration of evolvability, while negative directional epistasis leads to canalization. In contrast, pure non-directional epistasis has little effect on the response to selection. One consequence of this is that the classical epistatic variance components, which do not distinguish directional and non-directional effects, are useless as predictors of evolutionary dynamics. The build-up of linkage disequilibrium also has negligible effects. We argue that directional epistasis is likely to have major effects on evolutionary dynamics and should be the focus of empirical studies of epistasis. (c) 2005 Elsevier Inc. All rights reserved.