[Function of SIRT6 in tumor initiation and progression].
[Function of SIRT6 in tumor initiation and progression].
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DOI：
10.13345/j.cjb.150403
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发表时间：
2016-07-25
期刊：
影响因子：
--
通讯作者：
Cui, Hongjuan
中科院分区：
文献类型：
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作者：
Dong, Zhen;Lei, Qian;Cui, Hongjuan
SIRT6是sirtuins家族的一员，也被称为III类组蛋白去乙酰化酶（Class III histone deacetylases, hdac），具有多种催化酶活性，在抗衰老、染色质调节、转录控制、糖脂代谢和DNA损伤修复等生物过程中起着关键作用。近年来，越来越多的证据表明SIRT6与肿瘤的发生发展有关，如肝癌、肺癌、乳腺癌、生殖系统肿瘤等。然而，SIRT6可能在肿瘤发生和进展中发挥双重作用。SIRT6通常作为肿瘤抑制因子，但也可能发挥致癌作用。基于我们目前的研究，我们描述了SIRT6在各种肿瘤的发生和发展中的重要作用，并总结了其作用模式，这可能为癌症治疗提供线索。
As a member of the sirtuins family, also called Class III histone deacetylases (HDACs), SIRT6 has many catalytic enzyme activities and plays a pivotal role in biological processes including anti-aging, chromatin regulation, transcriptional control, glucose and lipid metabolism, and DNA damage repair. Recently, increasing evidences indicated that SIRT6 was related to initiation and development of tumors, such as hepatic cancer, lung cancer, breast cancer and genital system tumors. However, SIRT6 might play a dual role in tumorigenesis and progression. SIRT6 often acted as a tumor suppressor, but might play an oncogenic role. Based on our current study, we depicted the essential roles of SIRT6 in the initiation and progression of various tumors, and summarized its mode of actions, which might provide clues for cancer therapy.