RETROVIRAL SEQUENCES RELATED TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-II IN PATIENTS WITH CHRONIC FATIGUE IMMUNE DYSFUNCTION SYNDROME
RETROVIRAL SEQUENCES RELATED TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-II IN PATIENTS WITH CHRONIC FATIGUE IMMUNE DYSFUNCTION SYNDROME
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DOI：
10.1073/pnas.88.7.2922
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发表时间：
1991-04-01
影响因子：
11.1
通讯作者：
KOPROWSKI, H
中科院分区：
文献类型：
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作者：
DEFREITAS, E;HILLIARD, B;KOPROWSKI, H
慢性疲劳免疫功能障碍综合征（CFIDS）是最近认识到的疾病，其特征在于使人衰弱的疲劳以及免疫和神经异常[Straus，S. E.（1988）J.Inf.Dis.157，405-412]。 曾经被认为是由EB病毒引起的，现在被认为有一个不同的，但未知的病因。 我们评估了30个成人和儿童CFIDS患者从东部六个州的存在下，人类T淋巴细胞病毒（HTLV）的I型和II型的Western免疫印迹，聚合酶链反应，原位杂交的血液样本。 大多数患者的HTLV抗体的Western印迹和HTLV-II gag序列的聚合酶链反应和原位杂交呈阳性。 20名未暴露健康对照在所有试验中均为阴性。 这些数据支持HTLV-II样病毒和CFIDS之间的关联。
Chronic fatigue immune dysfunction syndrome (CFIDS) is a recently recognized illness characterized by debilitating fatigue as well as immunological and neurological abnormalities [Straus, S. E. (1988) J. Inf. Dis. 157, 405-412]. Once thought to be caused by Epstein-Barr virus, it is now thought to have a different but unknown etiology. We evaluated 30 adult and pediatric CFIDS patients from six eastern states for the presence of human T-lymphotropic virus (HTLV) types I and II by Western immunoblotting, polymerase chain reaction, and in situ hybridization of blood samples. The majority of patients were positive for HTLV antibodies by Western blotting and for HTLV-II gag sequences by polymerase chain reaction and in situ hybridization. Twenty nonexposure healthy controls were negative in all assays. These data support an association between an HTLV-II-like virus and CFIDS.