Deciphering the killer-cell immunoglobulin-like receptor system at super-resolution for natural killer and T-cell biology.
Deciphering the killer-cell immunoglobulin-like receptor system at super-resolution for natural killer and T-cell biology.
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DOI：
10.1111/imm.12684
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发表时间：
2017-03
期刊：
影响因子：
6.4
通讯作者：
Traherne JA
中科院分区：
文献类型：
--
作者：
Béziat V;Hilton HG;Norman PJ;Traherne JA
杀伤细胞免疫球蛋白样受体（KIR）是人类健康和生存所必需的两个基本生物系统的组成部分。首先，它们通过自然杀伤细胞和T细胞的表达促进宿主的先天性和适应性免疫应答。第二，KIR在调节胎盘形成和生殖成功中起关键作用。类似于其人类白细胞抗原I类配体的多样性，KIR是极其多态的。在这篇综述中，我们描述了最近的事态发展，推动了方法的进步，这有助于破译KIR系统的单倍型，多态性，表达模式和它们的配体相互作用。这些进展为KIR在免疫系统功能、进化和疾病中的相关性提供了更深入的见解。
Killer‐cell immunoglobulin‐like receptors (KIRs) are components of two fundamental biological systems essential for human health and survival. First, they contribute to host immune responses, both innate and adaptive, through their expression by natural killer cells and T cells. Second, KIR play a key role in regulating placentation, and hence reproductive success. Analogous to the diversity of their human leucocyte antigen class I ligands, KIR are extremely polymorphic. In this review, we describe recent developments, fuelled by methodological advances, that are helping to decipher the KIR system in terms of haplotypes, polymorphisms, expression patterns and their ligand interactions. These developments are delivering deeper insight into the relevance of KIR in immune system function, evolution and disease.