Developing precision medicine in a global world.
Developing precision medicine in a global world.
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DOI：
10.1158/1078-0432.ccr-14-0091
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发表时间：
2014-03-15
期刊：
影响因子：
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通讯作者：
Bates SE
中科院分区：
文献类型：
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作者：
Rubin EH;Allen JD;Nowak JA;Bates SE
Advances in understanding the biology of cancer, as well as advances in diagnostic technologies, such as the advent of affordable high resolution DNA sequencing, have had a major impact on the approach to identification of specific alterations in a given patient’s cancer that could be used as a basis for treatment selection, and hence the development of companion diagnostics. While there are now several examples of successful development of companion diagnostics that allow identification of patients who will achieve the greatest benefit from a new therapeutic, the path to co-approval of a diagnostic test along with a new therapeutic is complex and often inefficient. This review and the accompanying articles examine the current state of companion diagnostic development in the U.S. and Europe from academic, industry, regulatory, and economic perspectives.
