SCUDO: a tool for signature-based clustering of expression profiles
SCUDO: a tool for signature-based clustering of expression profiles
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DOI：
10.1093/nar/gkv449
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发表时间：
2015-07-01
影响因子：
14.9
通讯作者：
Priami, Corrado
中科院分区：
文献类型：
--
作者：
Lauria, Mario;Moyseos, Petros;Priami, Corrado
SCUDO（Signature-based Clustering for DiagnoStic purposes）是一个在线工具，用于诊断和分类目的的基因表达谱分析。该工具是基于一种新的方法，用于根据特定于受试者而不是特定于疾病的特征对概况进行聚类。我们的方法依赖于从健康和受影响的受试者中构建转录特征的参考图谱，这些转录特征来源于他们各自的mRNA或miRNA谱。然后可以通过确定个体的转录签名在图谱上的位置来进行对新个体的诊断。我们的方法的诊断能力已经在一个公开的科学竞赛（SBV改进诊断特征挑战赛）中得到了令人信服的证明，在一个子挑战赛中获得了第二名和第一名。
SCUDO (Signature-based ClUstering for DiagnOstic purposes) is an online tool for the analysis of gene expression profiles for diagnostic and classification purposes. The tool is based on a new method for the clustering of profiles based on a subject-specific, as opposed to disease-specific, signature. Our approach relies on construction of a reference map of transcriptional signatures, from both healthy and affected subjects, derived from their respective mRNA or miRNA profiles. A diagnosis for a new individual can then be performed by determining the position of the individual's transcriptional signature on the map. The diagnostic power of our method has been convincingly demonstrated in an open scientific competition (SBV Improver Diagnostic Signature Challenge), scoring second place overall and first place in one of the sub-challenges.