Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity
Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity
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DOI：
10.1038/ni1122
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发表时间：
2004-11-01
影响因子：
30.5
通讯作者：
Umetsu, DT
中科院分区：
文献类型：
--
作者：
Stock, P;Akbari, O;Umetsu, DT
控制免疫反应的调节性T细胞（T- r细胞）类型的范围尚不清楚。我们在这里描述了一群T- r细胞，它们在体内由初始CD4(+)CD25(-) T细胞在T辅助型1 （T(H)1）极化反应中发育而来，与CD25(+) T- r细胞不同。这些抗原特异性T-R细胞由cd8 α (+) dc诱导，产生白细胞介素10和干扰素γ，并有效抑制气道高反应性的发展。这些T- r细胞表达转录因子Foxp3和T-bet，表明这些T- r细胞与T(H)1细胞有关。因此，适应性T- r细胞是异质的，包括T(H)1样T- r细胞和之前描述的T(H)2样T- r细胞，它们表达Foxp3，并在CD8alpha(-) dc的呼吸耐受发育过程中被诱导。
The range of regulatory T cell (T-R cell) types that control immune responses is poorly understood. We describe here a population of T-R cells that developed in vivo from naive CD4(+)CD25(-) T cells during a T helper type 1 (T(H)1)-polarized response, distinct from CD25(+) T-R cells. These antigen-specific T-R cells were induced by CD8alpha(+) DCs, produced both interleukin 10 and interferon-gamma, and potently inhibited the development of airway hyper-reactivity. These T-R cells expressed the transcription factors Foxp3 and T-bet, indicating that these T-R cells are related to T(H)1 cells. Thus, adaptive T-R cells are heterogeneous and comprise T(H)1-like T-R cells as well as previously described T(H)2-like T-R cells, which express Foxp3 and are induced during the development of respiratory tolerance by CD8alpha(-) DCs.