Telomere length as an indicator of biological aging - The gender effect and relation with pulse pressure and pulse wave velocity
Telomere length as an indicator of biological aging - The gender effect and relation with pulse pressure and pulse wave velocity
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DOI：
10.1161/01.hyp.37.2.381
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发表时间：
2001-02-01
期刊：
影响因子：
8.3
通讯作者：
Aviv, A
中科院分区：
文献类型：
--
作者：
Benetos, A;Okuda, K;Aviv, A
实足年龄是中央动脉僵硬度的主要决定因素。僵硬度增加是心血管风险的独立指标。本研究的目的是确定是否端粒长度，一个可能的指标的生物老化，提供了一个更好的帐户比实足年龄的变化，动脉硬度，通过测量脉压和主动脉脉搏波速度进行评估。研究人群包括193名法国受试者（120名男性，73名女性），平均年龄为56 ± 11岁，未服用任何降压药物。通过测量末端限制性片段的平均长度来评估白色血细胞中的端粒长度。女性的端粒长度比男性长（8.67+/-0.09vs8.37 +/-0.07kb; P=0.016）。在两种性别中，端粒长度与年龄呈负相关（P
Chronological age is the primary determinant of stiffness of central arteries. Increased stiffness is an independent indicator of cardiovascular risk. The aim of this study was to determine whether telomere length, a possible index of biological aging, provides a better account than chronological age for variation in arterial stiffness, evaluated by measuring pulse pressure and aortic pulse wave velocity. The study population included 193 French subjects (120 men, 73 women), with a mean age of 56+/-11 years, who were not on any antihypertensive medications. Telomere length was evaluated in white blood cells by measuring the mean length of the terminal restriction fragments. Age-adjusted telomere length was longer in women than in men (8.67+/-0.09 versus 8.37+/-0.07 kb; P=0.016). In both genders, telomere length was inversely correlated with age (P