HIV incidence and behavioral correlates of HIV acquisition in a cohort of injection drug users in St Petersburg, Russia
HIV incidence and behavioral correlates of HIV acquisition in a cohort of injection drug users in St Petersburg, Russia
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DOI：
10.1097/md.0000000000005238
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发表时间：
2016-11-01
期刊：
影响因子：
1.6
通讯作者：
Shaboltas, Alla V.
中科院分区：
文献类型：
--
作者：
Kozlov, Andrei P.;Skochilov, Roman V.;Shaboltas, Alla V.
该项目的目的是研究注射吸毒者 (IDU) 中人类免疫缺陷病毒 (HIV) 的发病率、社会人口统计学和行为与艾滋病毒感染的相关性。总共招募了 717 名 IDU，并对其进行了 HIV-1 检测和咨询； 466 名 HIV 阴性参与者被招募并在 6 个月和 12 个月时进行随访。在每次研究访问期间收集社会人口统计学和行为数据。评估了社会人口统计学和行为因素与 HIV-1 发病率的关联。在 9 个月的招募期间，筛选了 717 名注射吸毒者，并招募了 466 名参与者。基线时 HIV-1 患病率为 35%。大多数登记受试者是年轻人（中位年龄 30 岁）、男性（75%），在过去 3 个月内注射过海洛因（86%），约 50% 的人共用注射器和其他用具，44% 的人在上个月有过无保护性行为。 12 个月随访时的保留率为 72%，调整后的保留率为 88%。 HIV发病率为7.2/100人年。艾滋病毒的发病率与特定的毒品危险行为显着相关，包括注射海洛因和精神兴奋剂的混合物、与其他人一起注射的频率以及有更多的毒贩。圣彼得堡注射吸毒者群体是世界上艾滋病毒发病率最高的群体之一。 2004年至2006年，艾滋病毒发病率为4.5人年，2005年至2007年为19.6人年，2008年至2009年为7.2人年。根据三项独立队列研究确定，圣彼得堡注射吸毒者中艾滋病毒流行的高峰期是 2006 年至 2007 年。迫切需要针对长期注射海洛因和高注射风险行为的注射吸毒者采取干预措施。
The aim of the project was to study human immunodeficiency virus (HIV) incidence, sociodemographic and behavioral correlates of HIV acquisition among injection drug users (IDUs).A total of 717 IDUs were recruited, tested, and counseled for HIV-1; 466 HIV-negative participants were enrolled and followed-up at 6 and 12 months. Sociodemographic and behavioral data were collected during each study visit. The association of sociodemographic and behavioral factors to HIV-1 incidence was assessed.During the 9-month recruitment period, 717 IDUs were screened and 466 participants were enrolled. HIV-1 prevalence at baseline was 35%. Most enrolled subjects were young (median age 30), male (75%), injected heroin in the previous 3 months (86%), about 50% had shared syringes and other paraphernalia, and 44% had unprotected sex in the last month. The retention rate at the 12-month follow-up was 72% and the adjusted retention rate was 88%. The HIV incidence rate was 7.2/100 person-years. HIV incidence was significantly associated with specific drug risk behaviors, including injecting the mixture of heroin and psychostimulants, the frequency of injecting in groups with other people, and having more drug dealers.The St Petersburg IDUs cohort demonstrates one of the highest HIV incidence rates in the world. In 2004 to 2006, the HIV incidence was 4.5, in 2005 to 2007-19.6, and in 2008 to 2009-7.2/100 person-years. The peak of HIV epidemic among IDUs in St Petersburg, as determined by 3 independent cohort studies, was in 2006 to 2007. Interventions targeting IDUs with long experience of heroin injection and high levels of injection risk behaviors are urgently needed.