Presence of multiple copies of capsulation loci in invasive Haemophilus influenzae type b (Hib) strains in Japan before introduction of the Hib conjugate vaccine
Presence of multiple copies of capsulation loci in invasive Haemophilus influenzae type b (Hib) strains in Japan before introduction of the Hib conjugate vaccine
复制标题
在引入 Hib 结合疫苗之前，日本的侵袭性 b 型流感嗜血杆菌 (Hib) 菌株中存在多个拷贝的荚膜位点
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
Y. Kawano
中科院分区：
文献类型：
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作者：
K. Ueno;J. Nishi;Naoko Imuta;K. Tokuda;Y. Kawano
尽管Hib疫苗有效，但capb基因座的多重扩增导致疫苗失败。然而，在日本还没有关于Hib基因座扩增效果的报道。我们检查了24株来自日本儿童的Hib菌株，这些儿童患有Hib所致的侵袭性疾病。虽然所有菌株显示相同的capb序列，Southern杂交分析表明，4株（16.7%）窝藏多个拷贝（两个以上）的capb基因座。由于Hib疫苗已被引入日本，因此有必要对流行的Hib菌株中的位点进行仔细分析。
Despite the effectiveness of the Hib vaccine, multiple amplification of the capb locus contributes to vaccine failure. However, there has been no report on the effect of Hib locus amplification in Japan. We examined 24 Hib strains from Japanese children with invasive diseases due to Hib. Although all strains showed the same capb sequence, Southern blot analysis showed that four strains (16.7%) harbored multiple copies (more than two) of the capb locus. Careful analysis of the locus in circulating Hib strains is necessary now that the Hib vaccine has been introduced into Japan.
影响因子：
6.4
作者：
CORN, PG;ANDERS, J;HOISETH, SK
通讯作者：
HOISETH, SK