Serum IL-6 Level May Have Role in the Pathophysiology of Unexplained Infertility
Serum IL-6 Level May Have Role in the Pathophysiology of Unexplained Infertility
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DOI：
10.1111/j.1600-0897.2009.00734.x
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发表时间：
2009-10-01
影响因子：
3.6
通讯作者：
Gul, Talip
中科院分区：
文献类型：
--
作者：
Demir, Bulent;Guven, Suleyman;Gul, Talip
问题本研究的目的是比较不明原因不孕女性与生育受试者的血清白细胞介素 (IL)-6 水平。研究方法在这项前瞻性对照研究中，评估并比较了 45 名不孕女性和 44 名生育女性在月经周期第 3 天的血清 IL-6 和肿瘤坏死因子-α (TNF-α) 水平。 与有生育能力的女性相比，不明原因不孕女性的 IL-6 水平显着较高（5.71 +/- 1.81 和 4.31 +/- 1.79，P < 0.001，Student's t 检验）。各组间TNF-α水平无显着性差异。结论不明原因不孕妇女与生育妇女血清IL-6水平存在显着差异，提示该细胞因子可能参与不明原因不孕的病理生理过程。
ProblemThe aim of this study was to compare the serum levels of interleukin (IL)-6 of women with unexplained infertility with fertile subjects.Method of studySerum IL-6, and tumor necrosis factor-alpha (TNF-alpha) levels of 45 infertile and 44 fertile women on day 3 of menstrual cycle were assessed and compared for this prospective controlled study.ResultsThe mean serum IL-6 level was significantly higher in women with unexplained infertility, compared with fertile women (5.71 +/- 1.81 and 4.31 +/- 1.79, P < 0.001, Student's t-test). There was no significant difference in TNF-alpha level among the groups.ConclusionSignificant difference in serum IL-6 levels between unexplained infertile and fertile women suggests that this cytokine may be involved in pathophysiology of unexplained infertility.