Coronavirus disease 2019 infection among asymptomatic and symptomatic pregnant women: two weeks of confirmed presentations to an affiliated pair of New York City hospitals
Coronavirus disease 2019 infection among asymptomatic and symptomatic pregnant women: two weeks of confirmed presentations to an affiliated pair of New York City hospitals
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DOI：
10.1016/j.ajogmf.2020.100118
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发表时间：
2020-05-01
影响因子：
6.3
通讯作者：
Goffman, Dena
中科院分区：
文献类型：
--
作者：
Breslin, Noelle;Baptiste, Caitlin;Goffman, Dena
自2020年3月1日报告首例病例以来，2019年新型冠状病毒病正在纽约大都会地区迅速传播。该州现在是美国2019年冠状病毒疾病爆发的震中，截至2020年4月2日，报告了84735例病例。我们之前介绍了7例2019年冠状病毒病阳性孕妇的早期病例系列，其中2例在最初的无症状表现后被诊断为2019年冠状病毒病。现在，我们描述了从2020年3月13日到2020年3月27日，在纽约市一对附属医院就诊的43例冠状病毒病2019年检测阳性病例，为期两周以上。共有14名(32.6%)患者(32.6%)没有出现任何冠状病毒病2019相关病毒症状，并在入院期间出现症状或在3月22日对所有产科住院患者实施普遍检测后被确认。其中，10名患者(71.4%)在分娩入院期间或产后出院后早期出现冠状病毒病2019年症状。在其他29名(67.4%)出现症状的2019年冠状病毒病患者中，3名女性最终因病毒症状而需要产前住院，另一名患者在成功引产后6天再次出现呼吸状况恶化需要氧气补充的情况。在新生儿出生的第一天进行初步检测时，没有发现2019年确诊的冠状病毒病例。根据Wu和McGoogan的冠状病毒病2019年疾病严重程度特征，37名女性(86%)表现出轻度疾病，4名(9.3%)重度疾病，2名(4.7%)危重疾病；这些百分比与2019年患有冠状病毒疾病的非怀孕成年人(约80%轻度，15%重度，5%危重疾病)相似。
Novel coronavirus disease 2019 is rapidly spreading throughout the New York metropolitan area since its first reported case on March 1, 2020. The state is now the epicenter of coronavirus disease 2019 outbreak in the United States, with 84,735 cases reported as of April 2, 2020. We previously presented an early case series with 7 coronavirus disease 2019-positive pregnant patients, 2 of whom were diagnosed with coronavirus disease 2019 after an initial asymptomatic presentation. We now describe a series of 43 test-positive cases of coronavirus disease 2019 presenting to an affiliated pair of New York City hospitals for more than 2 weeks, from March 13, 2020, to March 27, 2020. A total of 14 patients (32.6%) presented without any coronavirus disease 2019-associated viral symptoms and were identified after they developed symptoms during admission or after the implementation of universal testing for all obstetric admissions on March 22. Among them, 10 patients (71.4%) developed symptoms of coronavirus disease 2019 over the course of their delivery admission or early after postpartum discharge. Of the other 29 patients (67.4%) who presented with symptomatic coronavirus disease 2019, 3 women ultimately required antenatal admission for viral symptoms, and another patient re-presented with worsening respiratory status requiring oxygen supplementation 6 days postpartum after a successful labor induction. There were no confirmed cases of coronavirus disease 2019 detected in neonates upon initial testing on the first day of life. Based on coronavirus disease 2019 disease severity characteristics by Wu and McGoogan, 37 women (86%) exhibited mild disease, 4 (9.3%) severe disease, and 2 (4.7%) critical disease; these percentages are similar to those described in nonpregnant adults with coronavirus disease 2019 (about 80% mild, 15% severe, and 5% critical disease).