Brief Report: Functional Brown Adipose Tissue in Healthy Adults.
Brief Report: Functional Brown Adipose Tissue in Healthy Adults.
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DOI：
10.1056/nejmoa0808949
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发表时间：
2009-04-09
影响因子：
158.5
通讯作者：
Nuutila, Pirjo
中科院分区：
文献类型：
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作者：
Virtanen, Kirsi A.;Lidell, Martin E.;Nuutila, Pirjo
使用正电子发射断层扫描（PET），我们发现，冷诱导葡萄糖摄取增加了15倍，在5名健康受试者的子宫旁和锁骨上脂肪组织。我们从前三个连续的受试者中获得了该组织的活检标本，并记录了棕色脂肪细胞标志物解偶联蛋白1（UCP1）的信使RNA（mRNA）和蛋白质水平。结合形态学评估（显示大量多房细胞内脂滴）和生化分析结果，这些发现证明了健康成年人中存在大量代谢活性棕色脂肪组织。
Using positron-emission tomography (PET), we found that cold-induced glucose uptake was increased by a factor of 15 in paracervical and supraclavicular adipose tissue in five healthy subjects. We obtained biopsy specimens of this tissue from the first three consecutive subjects and documented messenger RNA (mRNA) and protein levels of the brown-adipocyte marker, uncoupling protein 1 (UCP1). Together with morphologic assessment, which showed numerous multilocular, intracellular lipid droplets, and with the results of biochemical analysis, these findings document the presence of substantial amounts of metabolically active brown adipose tissue in healthy adult humans.