p38 mitogen-activated protein kinase/activator protein-1 involved in serum deprivation-induced human alkaline ceramidase 2 upregulation
p38 mitogen-activated protein kinase/activator protein-1 involved in serum deprivation-induced human alkaline ceramidase 2 upregulation
复制标题
p38 丝裂原激活蛋白激酶/激活蛋白 1 参与血清剥夺诱导的人碱性神经酰胺酶 2 上调
DOI：
10.3892/br.2014.394
复制
发表时间：
2015-03-01
影响因子：
2.3
通讯作者：
Jin, Junfei
中科院分区：
文献类型：
--
作者：
Huang, Zhaoquan;Huang, Guojin;Jin, Junfei
Our previous study revealed that serum deprivation upregulated human alkaline ceramidase 2 (haCER2) activity and mRNA in HeLa cells, but the mechanism remains unknown. In the present study, serum deprivation also upregulated haCER2 activity in HepG2 human hepatoma cell line cells due to an increase in haCER2 mRNA, in which mRNA transcription, not mRNA stability, is involved. Furthermore, p38 mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) signaling pathway is involved in haCER2 mRNA upregulation by serum deprivation, and this mechanism may explain why haCER2 is upregulated in human liver cancer. In conclusion, p38 MAPK, AP-1 or haCER2 may be used as targets in liver cancer therapy.
