Selective destruction of preganglionic sympathetic nerves by antibodies to acetylcholinesterase.
Selective destruction of preganglionic sympathetic nerves by antibodies to acetylcholinesterase.
复制标题
乙酰胆碱酯酶抗体选择性破坏节前交感神经。
DOI：
10.1007/978-3-7091-9175-0_18
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Lennon,VA
中科院分区：
文献类型：
--
作者：
Brimijoin,S;Lennon,VA
Systemic injection of monoclonal antibodies to neural acetylcholinesterase in rats causes permanent, complement-mediated destruction of presynaptic fibers in sympathetic ganglia and adrenal medulla. Ptosis, hypotension, bradycardia, and postural syncope ensue. In sympathetic ganglia, cholinergic synapses disappear, but postganglionic adrenergic neurones remain structurally and functionally normal. Somatic motor and parasympathetic systems are also spared. This model of selective cholinergic autoimmunity is a new tool for autonomic physiology and may be relevant to the pathogenesis of human dysautonomias.
