Asymmetric nickel-catalyzed negishi cross-couplings of secondary α-bromo amides with organozinc reagents
Asymmetric nickel-catalyzed negishi cross-couplings of secondary α-bromo amides with organozinc reagents
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DOI：
10.1021/ja0506509
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发表时间：
2005-04-06
影响因子：
15
通讯作者：
Fu, GC
中科院分区：
文献类型：
--
作者：
Fischer, C;Fu, GC
Ni/Pybox催化剂实现了α-溴代仲酰胺与有机锌试剂的不对称交叉偶联。该方法容许多种官能团，并以良好的产率和高对映体过量提供所需产物。
A Ni/Pybox catalyst achieves the asymmetric cross-coupling of secondary α-bromo amides with organozinc reagents. The process tolerates a variety of functional groups and affords the desired product in good yield and in high enantiomeric excess.