Cluster randomized trials in general (family) practice research
Cluster randomized trials in general (family) practice research
复制标题
DOI：
10.1191/096228000676246354
复制
发表时间：
2000-04-01
影响因子：
2.3
通讯作者：
Campbell, MJ
中科院分区：
文献类型：
--
作者：
Campbell, MJ
整群随机试验在全科医学（家庭医学）中越来越常见。本文将考虑此类试验的设计和分析，并强调与教育，健康促进和公共卫生试验的相似性和差异。讨论的问题是估计和范围内的集群内的相关系数的值在一般的做法，以及相关的样本量问题。每个聚类的受试者数量差异很大，这会导致规划和分析困难。在这些试验中的伦理问题，并考虑，如意向治疗的原则也被认为是。给出了一个连续结果变量的分析类型的例子，并简要总结了可用的软件。
Cluster randomized trials are increasingly common in general practice (family medicine). This paper will consider the design and analysis of such trials and emphasize the similarities and differences with trials in education, heath promotion and public health. Issues discussed are the estimation and range of values of the intra-cluster correlation coefficient found in general practice, and the associated sample size problems. There are problems with widely varying numbers of subjects per cluster, which leads to planning and analysis difficulties. Ethical issues in these trials, and considerations such as the principle of intention to treat are also considered. An example of the type of analysis available for a continuous outcome variable is given, and the available software is summarized briefly.